Evidence map›Paper›PMID 37395978›Full record

ArticleJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing2024

Electrogram morphology recurrence guided catheter ablation for repeat ablation of persistent atrial fibrillation.

Raul D Mitrani, Ghaith Zaatari, Jorge Bohorquez, Jason Ng, Justin Ng, Harold Rivner, Alex Velasquez, Litsa Lambrakos, Rishi Arora, Jeffrey J Goldberger

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Raul D MitraniDivision of Cardiology, University of Miami, 1120 NW 14th St.Clinical Research Building, 1124, 33161, Miami, FL, USA.
Ghaith ZaatariDivision of Cardiology, University of Miami, 1120 NW 14th St.Clinical Research Building, 1124, 33161, Miami, FL, USA.
Jorge BohorquezDepartment of Biomedical Engineering, University of Miami, Miami, FL, USA.
Jason NgNorthwestern University, Evanston, IL, USA.
Justin NgNorthwestern University, Evanston, IL, USA.
Harold RivnerDivision of Cardiology, University of Miami, 1120 NW 14th St.Clinical Research Building, 1124, 33161, Miami, FL, USA.
Alex VelasquezDivision of Cardiology, University of Miami, 1120 NW 14th St.Clinical Research Building, 1124, 33161, Miami, FL, USA.
Litsa LambrakosDivision of Cardiology, University of Miami, 1120 NW 14th St.Clinical Research Building, 1124, 33161, Miami, FL, USA.
Rishi AroraNorthwestern University, Evanston, IL, USA.
Jeffrey J GoldbergerDivision of Cardiology, University of Miami, 1120 NW 14th St.Clinical Research Building, 1124, 33161, Miami, FL, USA. j-goldberger@miami.edu.ORCID http://orcid.org/0000-0001-9802-1851
University of Miami · USNorthwestern University · US

Funding

New and Disruptive Therapeutic Approaches to Target Fundamental Molecular Mechanisms Underlying Atrial FibrillationR35HL161249 · NHLBI · UNIVERSITY OF CHICAGO · PI Rishi Arora · 2022 to 2026
$5.1M
The identification and pathophysiology of non-infarcted but injured myocardium in the post-ischemic heartR01HL152712 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ARORA, RISHI, ZHAO, MING · 2021 to 2024
$3.0M
Pathophysiological Significance of Atrial Fibrillation Electrogram PatternsR01HL125881 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ARORA, RISHI · 2015 to 2019
$2.4M
Oxidative stress contributes to atrial fibrillation by causing remodeling of the autonomic nervous systemR01HL140061 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ARORA, RISHI · 2018 to 2021
$2.3M
Mapping electrogram morphology recurrence for atrial fibrillation ablationR41HL127907 · NHLBI · GOLD T-TECH, INC. · PI NG, JASON · 2015 to 2015
$225k
NHLBI NIH HHS 1R01HL125881NHLBI NIH HHS 1R41HL127907NHLBI NIH HHS R01 HL125881NHLBI NIH HHS R01 HL140061NHLBI NIH HHS R01 HL152712NHLBI NIH HHS R35 HL161249NHLBI NIH HHS R41 HL127907
6 · The paper itself

Abstract

backgroundThere are no standard mapping approaches for patients with persistent atrial fibrillation (PeAF), particularly after failed prior catheter ablation (CA). In this study, we assess the feasibility of using Electrogram Morphology Recurrence (EMR) to guide ablation.

methodsTen patients with recurrent PeAF after prior CA underwent detailed mapping of both atria during PeAF using the PentaRay (4 mm interelectrode spacing) and 3D mapping with CARTO. At each site, 15 s recordings were made. Custom software identified each electrogram and cross-correlation was used to identify the most recurrent electrogram morphology from which the % recurrence and cycle length of the most repeatable morphology (CL

resultsA mean of 342.9 ± 131.9 LA and 328.6 ± 91.5 RA sites were recorded per patient. Nine had PV reconnection. Shortest CL

conclusionEMR is a feasible, novel technique to guide CA in patients with PeAF. Further evaluation is needed to provide an electrogram-based method for mapping guided targeted ablation of key areas.

Indexed as

Atrial FibrillationCatheter AblationPulmonary VeinsHeart AtriaHumansRecurrenceTreatment OutcomeAblationElectrogramsMappingPersistent atrial fibrillation

Identifiers

PMID37395978
PMCPMC10761586
OpenAlexW4382918655

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.