Evidence map›Paper›PMID 37395924›Full record

ArticleInfection2023

Recurrence of bacteremia and infective endocarditis according to bacterial species of index endocarditis episode.

Lauge Østergaard, Marianne Voldstedlund, Niels Eske Bruun, Henning Bundgaard, Kasper Iversen, Mia Marie Pries-Heje, Katra Hadji-Turdeghal, Peter L Graversen, Claus Moser, Christian Østergaard Andersen and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Infection, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Infective endocarditis and post-treatment bacteremia caused by oral microorganisms: a retrospective cohort study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Rethinking the Routine: Are Repeat Blood Cultures Necessary After Completion of Infective Endocarditis Treatment?Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Article
  10. Synergistic eradication ofFrontiers in medicine · 2026
    Article
  11. Observational
  12. Article
  13. Article
  14. Article
  15. Enterococcal endocarditis management and relapses.JAC-antimicrobial resistance · 2024
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

Lauge ØstergaardThe Heart Centre, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen, Denmark. laugeoestergaard@gmail.com.
Marianne VoldstedlundStatens Serum Institut, Copenhagen, Denmark.
Niels Eske BruunDepartment of Cardiology, Zealand University Hospital, Roskilde, Denmark.
Henning BundgaardThe Heart Centre, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen, Denmark.
Kasper IversenDepartment of Cardiology, Herlev-Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Mia Marie Pries-HejeThe Heart Centre, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen, Denmark.
Katra Hadji-TurdeghalThe Heart Centre, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen, Denmark.
Peter L GraversenThe Heart Centre, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen, Denmark.
Claus MoserDepartment of Clinical Microbiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Christian Østergaard AndersenDepartment of Clinical Microbiology, Amager-Hvidovre Hospital, Copenhagen, Denmark.
Kirstine Kobberøe SøgaardDepartment of Clinical Microbiology, Aalborg University Hospital, Aalborg, Denmark.
Lars KøberThe Heart Centre, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen, Denmark.
Emil Loldrup FosbølThe Heart Centre, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen, Denmark.
Rigshospitalet · DKUniversity of Copenhagen · DKAalborg University · DKGentofte Hospital · DKHvidovre Hospital · DKStatens Serum Institut · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeIn patients surviving infective endocarditis (IE) recurrence of bacteremia or IE is feared. However, knowledge is sparse on the incidence and risk factors for the recurrence of bacteremia or IE.

methodsUsing Danish nationwide registries (2010-2020), we identified patients with first-time IE which were categorized by bacterial species (Staphylococcus aureus, Enterococcus spp., Streptococcus spp., coagulase-negative staphylococci [CoNS], 'Other' microbiological etiology). Recurrence of bacteremia (including IE episodes) or IE with the same bacterial species was estimated at 12 months and 5 years, considering death as a competing risk. Cox regression models were used to compute adjusted hazard ratios of the recurrence of bacteremia or IE.

resultsWe identified 4086 patients with IE; 1374 (33.6%) with S. aureus, 813 (19.9%) with Enterococcus spp., 1366 (33.4%) with Streptococcus spp., 284 (7.0%) with CoNS, and 249 (6.1%) with 'Other'. The overall 12-month incidence of recurrent bacteremia with the same bacterial species was 4.8% and 2.6% with an accompanying IE diagnosis, while this was 7.7% and 4.0%, respectively, with 5 years of follow-up. S. aureus, Enterococcus spp., CoNS, chronic renal failure, and liver disease were associated with an increased rate of recurrent bacteremia or IE with the same bacterial species.

conclusionRecurrent bacteremia with the same bacterial species within 12 months, occurred in almost 5% and 2.6% for recurrent IE. S. aureus, Enterococcus spp., and CoNS were associated with recurrent infections with the same bacterial species.

Indexed as

BacteremiaEndocarditisEndocarditis, BacterialStaphylococcal InfectionsBacteriaEnterococcusHumansStaphylococcusStaphylococcus aureusStreptococcusBacteremiaInfective endocarditisRecurrenceReinfectionRelapse

Identifiers

PMID37395924
PMCPMC10665237
OpenAlexW4382918919

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.