Evidence map›Paper›PMID 37395889›Full record

ArticleVirus genes2023

Screening and identification of specific cluster miRNAs in N2a cells infected by H7N9 virus.

Yitong Yin, Zengzhao Qiu, Yuxuan Lei, Jia Huang, Ying Sun, Hui Liu, Weihua Wu, Xin Wang, Yuelong Shu, Qing Zheng and 1 more

Abstract read
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In one paragraph

Article in Virus genes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Yitong YinJinan University, College of Pharmacy, Guangzhou, 510632, China.
Zengzhao QiuNational Sun yat-sen University, Public Health Hospital (Shenzhen), Shenzhen, 518107, China.
Yuxuan LeiNational Sun yat-sen University, Public Health Hospital (Shenzhen), Shenzhen, 518107, China.
Jia HuangGuangdong Pharmaceutical University, Public Health College, Guangzhou, 510006, China.
Ying SunShenzhen Center for Disease Control and Prevention, Shenzhen, 518055, China.
Hui LiuShenzhen Center for Disease Control and Prevention, Shenzhen, 518055, China.
Weihua WuShenzhen Center for Disease Control and Prevention, Shenzhen, 518055, China.
Xin WangShenzhen Center for Disease Control and Prevention, Shenzhen, 518055, China.
Yuelong ShuNational Sun yat-sen University, Public Health Hospital (Shenzhen), Shenzhen, 518107, China.
Qing ZhengJinan University, College of Pharmacy, Guangzhou, 510632, China. tzhengq@jnu.edu.cn.
Shisong FangShenzhen Center for Disease Control and Prevention, Shenzhen, 518055, China. szcdcssf@aliyun.com.
Shenzhen Center for Disease Control and Prevention · CNJinan University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNGuangdong Pharmaceutical University · CN

Funding

National Natural Science Foundation of China No.81871631Shenzhen Science and Technology Plan Project JCYJ20180307102005105
6 · The paper itself

Abstract

This study aims to screen and identify specific cluster miRNAs of H7N9 virus-infected N2a cells and explore the possible pathogenesis of these miRNAs. The N2a cells are infected with H7N9 and H1N1 influenza viruses, and the cells are collected at 12, 24 and 48 h to extract total RNA. To sequence miRNAs and identify different virus-specific miRNAs, high-throughput sequencing technology is used. Fifteen H7N9 virus-specific cluster miRNAs are screened, and eight of them are included in the miRBase database. These cluster-specific miRNAs regulate many signaling pathways, such as the PI3K-Akt signaling pathway, the RAS signaling pathway, the cAMP signaling pathway, actin cytoskeleton regulation and cancer-related genes. The study provides a scientific basis for the pathogenesis of H7N9 avian influenza, which is regulated by miRNAs.

Indexed as

Influenza A Virus, H1N1 SubtypeInfluenza A Virus, H7N9 SubtypeInfluenza, HumanInfluenza in BirdsMicroRNAsAnimalsHumansPhosphatidylinositol 3-KinasesMicroRNAsPhosphatidylinositol 3-KinasesH1N1 virusH7N9 virusmicroRNANeuroblastoma cell (N2a)

Identifiers

PMID37395889
OpenAlexW4382919322

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.