ReviewEFORT open reviews2023
Review of perioperative outcomes and management of hip fracture patients on direct oral anticoagulants.
Review in EFORT open reviews, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed.
- Management and optimisation in the preoperative phase for patients with a fractured hip.EFORT open reviews · 2026Review
- Factors influencing the implementation of best clinical practices for hip fracture management in resource-constrained hospitals in China and co-design of quality improvement interventions: a qualitative study.The Lancet regional health. Western Pacific · 2026Article
- Blood Transfusion Risk Following Early Versus Delayed Surgery in Hip Fracture Patients on Direct Oral Anticoagulants: A Study Protocol for a Natural Experiment.Journal of clinical medicine · 2026Article
- Early versus delayed hip arthroplasty for femoral neck fractures in the elderly: a comparative study on multidimensional recovery.Frontiers in medicine · 2026Article
- Perioperative red blood cell transfusion in gallbladder cancer surgery: Trends and determinants from nationwide data.Annals of hepato-biliary-pancreatic surgery · 2025Article
- Clinical outcomes in elderly patients on direct oral anticoagulant drugs undergoing surgery for acute hip fracture (AHF).European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Observational
- Correlation between anxiety, depression, sense of coherence, and post-traumatic growth in patients who underwent intertrochanteric femoral fracture surgery.World journal of psychiatry · 2025Article
- A comparison of the effects of direct oral anticoagulants versus vitamin K antagonists and antiplatelet agents on the timing and outcomes of hip fracture surgery in patients older than 65 years: the ORTHO-GER-DOAC study.European geriatric medicine · 2025Observational
- Preoperative anticoagulation and its impact on surgical timing and postoperative outcomes in hip fracture surgery: a retrospective study at an Orthogeriatrics Clinical Care Center in Colombia.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2025Article
- Transfusion Risk Factors in Low-Energy Pelvic Fractures: A Retrospective Cohort Study.Geriatric orthopaedic surgery & rehabilitation · 2025Article
- Admission Hemoglobin Associated with Increased Mortality in Hip Fracture Surgical Patients: An Observational Study.Biomedicines · 2024Article
- The Safety and Efficacy of Microporous Polysaccharide Hemospheres in Terms of the Complication Rates in Total Hip Arthroplasty for Femoral Neck Fractures: A Control-Matched Retrospective Cohort.Life (Basel, Switzerland) · 2024Article
- Benefits of surgical treatment within 48 h of proximal femoral fracture in centenarians: a retrospective cohort study.Frontiers in surgery · 2024Article
- Preoperative Drug Monitoring in Management of Patients with Hip Fracture on Treatment with Direct Oral Anticoagulants.Clinical interventions in aging · 2024Article
- Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anticoagulation use is common in elderly patients presenting with hip fractures and has been shown to delay time to surgery (TTS). Delays in operative treatment have been associated with worse outcomes in hip fracture patients. Direct oral anticoagulants (DOACs) comprise a steadily increasing proportion of all oral anticoagulation. Currently, no clear guidelines exist for perioperative management of hip fracture patients taking DOACs. DOAC use is associated with increased TTS, with delays frequently greater than 48 h from hospital presentation. Increased mortality has not been widely demonstrated in DOAC patients, despite increased TTS. Timing of surgery was not found to be associated with increased risk of transfusion or bleeding. Early surgery appears to be safe in patients taking DOACs presenting with a hip fracture, but is not currently widely accepted due to factors such as site-specific anesthesiologic protocols that periodically delay surgery. Direct oral anticoagulant use should not routinely delay surgical treatment in hip fracture patients. Surgical strategies to limit blood loss should be considered and include efficient surgical fixation, topical application of hemostatic agents, and the use of intra-operative cell salvage. Anesthesiologic strategies have utility in minimizing risk and a collaborative effort to minimize blood loss should be undertaken by the surgeon and anesthesiologist. Anesthesia team interventions include considerations regarding positioning, regional anesthesia, permissive hypotension, avoidance of hypothermia, judicious administration of blood products, and the use of systemic hemostatic agents.
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