ArticlePsychological medicine2023
Neurodevelopmental vulnerability to psychosis: developmentally-based methods enable detection of early life inhibitory control deficits that predict psychotic-like experiences at the transition to adolescence.
Article in Psychological medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Clues from dyadic interactions in early childhood predict psychotic-like experiences at the transition to adolescence in a sample enriched for psychopathology risk.Journal of psychopathology and clinical science · 2025Article
- Imitative inhibitory control is associated with psychotic experiences in a sample from the general population.Frontiers in psychiatry · 2024Article
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Authors and funding
9 authors.
Funding
Abstract
backgroundInhibitory control develops in early childhood, and atypical development may be a measurable marker of risk for the later development of psychosis. Additionally, inhibitory control may be a target for intervention.
methodsBehavioral performance on a developmentally appropriate Go/No-Go task including a frustration manipulation completed by children ages 3-5 years (early childhood;
resultsChildren with lower accuracy on No-Go trials compared to Go trials in early childhood (
conclusionsLong-term follow-up demonstrates for the first time a specific deficit in inhibitory control behaviorally and electrophysiology, for individuals who later report more PLEs. Decreases in task performance under frustration induction indicated risk for internalizing and externalizing symptoms. These findings suggest that pathophysiological mechanisms for psychosis are relevant and discriminable in early childhood, and further, suggest an identifiable and potentially modifiable target for early intervention.
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