Evidence map›Paper›PMID 37395479›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2023

Vascular determinants of hippocampal viscoelastic properties in healthy adults across the lifespan.

Faria Sanjana, Peyton L Delgorio, Theodore M DeConne, Lucy V Hiscox, Ryan T Pohlig, Curtis L Johnson, Christopher R Martens

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Faria SanjanaDepartment of Kinesiology and Applied Physiology, University of Delaware, Newark, DE, USA.ORCID 0000-0001-6529-6680
Peyton L DelgorioDepartment of Biomedical Engineering, University of Delaware, Newark, DE, USA.
Theodore M DeConneDepartment of Kinesiology and Applied Physiology, University of Delaware, Newark, DE, USA.
Lucy V HiscoxCardiff University Brain Research Imaging Centre (CUBRIC), Cardiff University, Cardiff, UK.ORCID 0000-0001-6296-7442
Ryan T PohligDepartment of Epidemiology, University of Delaware, Newark, DE, USA.
Curtis L JohnsonDepartment of Biomedical Engineering, University of Delaware, Newark, DE, USA.
Christopher R MartensDepartment of Kinesiology and Applied Physiology, University of Delaware, Newark, DE, USA.ORCID 0000-0003-0578-2948
University of Delaware · USCardiff University · GB

Funding

Vascular Consequences of Duchenne Muscular DystrophyP20GM113125 · NIGMS · UNIVERSITY OF DELAWARE · PI LENNON, SHANNON L. · 2016 to 2025
$23.3M
Updated confocal microscope in the Imaging Core facility to support biomedical researchP20GM103653 · NIGMS · DELAWARE STATE UNIVERSITY · PI HARRINGTON, MELISSA A · 2012 to 2022
$22.7M
Mechanical integrity of memory systems in mild cognitive impairmentR01AG058853 · NIA · UNIVERSITY OF DELAWARE · PI JOHNSON, CURTIS L · 2018 to 2022
$2.3M
NAD+ Therapy for Improving Memory & Cerebrovasular Function in Patients with MCIK01AG054731 · NIA · UNIVERSITY OF DELAWARE · PI MARTENS, CHRISTOPHER · 2017 to 2021
$723k
NIA NIH HHS K01 AG054731NIA NIH HHS R01 AG058853NIGMS NIH HHS P20 GM103653NIGMS NIH HHS P20 GM113125
6 · The paper itself

Abstract

Arterial stiffness and cerebrovascular pulsatility are non-traditional risk factors of Alzheimer's disease. However, there is a gap in understanding the earliest mechanisms that link these vascular determinants to brain aging. Changes to mechanical tissue properties of the hippocampus (HC), a brain structure essential for memory encoding, may reflect the impact of vascular dysfunction on brain aging. We tested the hypothesis that arterial stiffness and cerebrovascular pulsatility are related to HC tissue properties in healthy adults across the lifespan. Twenty-five adults underwent measurements of brachial blood pressure (BP), large elastic artery stiffness, middle cerebral artery pulsatility index (MCAv PI), and magnetic resonance elastography (MRE), a sensitive measure of HC viscoelasticity. Individuals with higher carotid pulse pressure (PP) exhibited lower HC stiffness (β = -0.39, r = -0.41, p = 0.05), independent of age and sex. Collectively, carotid PP and MCAv PI significantly explained a large portion of the total variance in HC stiffness (adjusted R

Indexed as

LongevityVascular StiffnessAdultBlood Flow VelocityCarotid ArteriesCross-Sectional StudiesHippocampusHumansArterial stiffnessbrain imagingcerebrovascular pulsatilityhippocampal tissue viscoelastic propertiesmagnetic resonance elastography

Identifiers

PMID37395479
PMCPMC10676145
OpenAlexW4382918536

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.