Evidence map›Paper›PMID 37395349›Full record

ArticleACS applied materials & interfaces2023

Phthalocyanine-Blue Nanoparticles for the Direct Visualization of Tumors with White Light Illumination.

Ahmad Amirshaghaghi, Wen-Chi Chang, Bonirath Chhay, Ariane R Bartolomeu, Margie L Clapper, Zhiliang Cheng, Andrew Tsourkas

Open access · greenAbstract read
In one paragraph

Article in ACS applied materials & interfaces, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ahmad AmirshaghaghiDepartment of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Wen-Chi ChangCancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, United States.
Bonirath ChhayDepartment of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Ariane R BartolomeuCancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, United States.ORCID 0000-0002-4976-5659
Margie L ClapperCancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, United States.
Zhiliang ChengDepartment of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.ORCID 0000-0003-3351-6874
Andrew TsourkasDepartment of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.ORCID 0000-0001-7758-1753
University of Pennsylvania · USFox Chase Cancer Center · US

Funding

WORD PROCESSING CENTER--COREP30CA006927 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI Dietmar J Kappes · 1985 to 2026
$138.8M
Phenotypic Diversity in COVID-19UL1TR001878 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2016 to 2025
$102.4M
Combined magnetophoresis and photodynamic therapy for the treatment of TNBCR01EB028858 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI TSOURKAS, ANDREW · 2021 to 2024
$1.8M
Image-guided surgery and sonodynamic therapy with stroma-targeted theranostic nanoclustersR01EB029238 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI TSOURKAS, ANDREW · 2020 to 2023
$1.4M
NCATS NIH HHS UL1 TR001878NCI NIH HHS P30 CA006927NIBIB NIH HHS R01 EB028858NIBIB NIH HHS R01 EB029238
6 · The paper itself

Abstract

The current standard of care for colon cancer surveillance relies heavily on white light endoscopy (WLE). However, dysplastic lesions that are not visible to the naked eye are often missed when conventional WLE equipment is used. Although dye-based chromoendoscopy shows promise, current dyes cannot delineate tumor tissues from surrounding healthy tissues accurately. The goal of the present study was to screen various phthalocyanine (PC) dye-loaded micelles for their ability to improve the direct visualization of tumor tissues under white light following intravenous administration. Zinc PC (tetra-

Indexed as

NeoplasmsAnimalsCell Line, TumorColoring AgentsHumansIsoindolesLightMaleMiceMice, Inbred BALB CMicellesNanoparticlesColoring AgentsIsoindolesMicellesphthalocyaninechromoendoscopycolorectal cancernanoparticlesphthalocyaninewhite light endoscopy

Identifiers

PMID37395349
PMCPMC10724988
OpenAlexW4382918167

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.