Evidence map›Paper›PMID 37395259›Full record

ArticleJournal of dental research2023

Bacterial Community Modifies Host Genetics Effect on Early Childhood Caries.

F Blostein, T Zou, D Bhaumik, E Salzman, K M Bakulski, J R Shaffer, M L Marazita, B Foxman

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of dental research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Birth Cohort Study IdentifiesJournal of dental research · 2025
    Article
  2. Article
  3. Article
  4. Dental Caries: The Way Forward.JDR clinical and translational research · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

F BlosteinDepartment of Epidemiology, University of Michigan School of Public Health, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-5734-4969
T ZouDepartment of Human Genetics, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-2249-5871
D BhaumikDepartment of Epidemiology, University of Michigan School of Public Health, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0003-4423-6341
E SalzmanDepartment of Epidemiology, University of Michigan School of Public Health, University of Michigan, Ann Arbor, MI, USA.
K M BakulskiDepartment of Epidemiology, University of Michigan School of Public Health, University of Michigan, Ann Arbor, MI, USA.
J R ShafferDepartment of Oral and Craniofacial Sciences, Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0003-1897-1131
M L MarazitaDepartment of Oral and Craniofacial Sciences, Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
B FoxmanDepartment of Epidemiology, University of Michigan School of Public Health, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0001-6682-238X
University of Michigan · USUniversity of Pittsburgh · US

Funding

Psychosocial Influences on Rural Children's Oral HealthR01DE014899 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FOXMAN, BETSY, MARAZITA, MARY L. · 2002 to 2020
$39.9M
University of Michigan Training Program in Genomic ScienceT32HG000040 · NHGRI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Sebastian Zoellner · 1995 to 2026
$16.4M
Environmental and Genetic Factors Contributing to the Development of the Early-Life Oral Microbiome and its Influence on Early Childhood CariesF31DE029992 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BLOSTEIN, FREIDA ANNE · 2020 to 2022
$87k
NHGRI NIH HHS T32 HG000040NIDCR NIH HHS F31 DE029992NIDCR NIH HHS R01 DE014899
6 · The paper itself

Abstract

By age 5, approximately one-fifth of children have early childhood caries (ECC). Both the oral microbiome and host genetics are thought to influence susceptibility. Whether the oral microbiome modifies genetic susceptibility to ECC has not been tested. We test whether the salivary bacteriome modifies the association of a polygenic score (PGS, a score derived from genomic data that summarizes genetic susceptibility to disease) for primary tooth decay on ECC in the Center for Oral Health Research in Appalachia 2 longitudinal birth cohort. Children were genotyped using the Illumina Multi-Ethnic Genotyping Array and underwent annual dental examinations. We constructed a PGS for primary tooth decay using weights from an independent, genome-wide association meta-analysis. Using Poisson regression, we tested for associations between the PGS (high versus low) and ECC incidence, adjusting for demographic characteristics (

Indexed as

Dental CariesDental Caries SusceptibilityBacteriaChild, PreschoolGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMeta-Analysis as TopicSalivadental cariesepidemiologygenomicsmicrobiomepediatricssaliva

Identifiers

PMID37395259
PMCPMC10552462
OpenAlexW4382918881

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.