Evidence map›Paper›PMID 37395135›Full record

ArticleLab on a chip2023

Continuous molecular monitoring of human dermal interstitial fluid with microneedle-enabled electrochemical aptamer sensors.

Mark Friedel, Benjamin Werbovetz, Amy Drexelius, Zach Watkins, Ahilya Bali, Kevin W Plaxco, Jason Heikenfeld

2 registry-linked trialsOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lab on a chip, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05981573 recruitingnot on this mapstarted 2024, after this paper: background citation

Assessment of Methadone Dose Taken

TypeobservationalSponsorCari Health Inc.Ran2024 to 2026Enrolled30ConditionsMethadone Toxicity, Methadone Overdose, Pain, Chronic, Drug Metabolism, Poor, CYP2D6-RelatedArmsMeasurement of Methadone in the Interstitial Fluid (ISF) before and after prescribed dose taken ex vivo, Measurement of Methadone in the Interstitial Fluid before and after prescribed dose taken in vivo, ISF Extraction Device 2
NCT06837571 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Assessment of Methadone Dose Taken

TypeobservationalSponsorCari Health Inc.Ran2025 to 2025Enrolled30ConditionsMethadone Toxicity, Methadone Overdose, Pain, Chronic, Drug Metabolism, Poor, CYP2D6-RelatedArmsMeasurement of Methadone in the Interstitial Fluid (ISF) before and after prescribed dose taken ex vivo, Measurement of Methadone in the Interstitial Fluid before and after prescribed dose taken in vivo, ISF Extraction Device 2
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 40 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Mark FriedelNovel Devices Laboratory, College of Engineering, University of Cincinnati, Cincinnati, Ohio 45221, USA. friedemc@mail.uc.edu.ORCID 0000-0001-8115-6549
Benjamin WerbovetzNovel Devices Laboratory, College of Engineering, University of Cincinnati, Cincinnati, Ohio 45221, USA. friedemc@mail.uc.edu.
Amy DrexeliusNovel Devices Laboratory, College of Engineering, University of Cincinnati, Cincinnati, Ohio 45221, USA. friedemc@mail.uc.edu.
Zach WatkinsNovel Devices Laboratory, College of Engineering, University of Cincinnati, Cincinnati, Ohio 45221, USA. friedemc@mail.uc.edu.ORCID 0000-0002-4789-1846
Ahilya BaliNovel Devices Laboratory, College of Engineering, University of Cincinnati, Cincinnati, Ohio 45221, USA. friedemc@mail.uc.edu.
Kevin W PlaxcoDepartment of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106, USA.ORCID 0000-0003-4772-8771
Jason HeikenfeldNovel Devices Laboratory, College of Engineering, University of Cincinnati, Cincinnati, Ohio 45221, USA. friedemc@mail.uc.edu.
University of Cincinnati · USUniversity of California, Santa Barbara · US

Funding

Bio-electrochemical detectors for in vivo continuous monitoringR01EB022015 · NIBIB · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI KIPPIN, TOD EDWARD, PLAXCO, KEVIN W · 2017 to 2025
$4.6M
NIBIB NIH HHS R01 EB022015
6 · The paper itself

Abstract

The ability to continually collect diagnostic information from the body during daily activity has revolutionized the monitoring of health and disease. Much of this monitoring, however, has been of physical "vital signs", with the monitoring of molecular markers having been limited to glucose, primarily due to the lack of other medically relevant molecules for which continuous measurements are possible in bodily fluids. Electrochemical aptamer sensors, however, have a recent history of successful

Indexed as

Biosensing TechniquesAnimalsExtracellular FluidGlucoseHumansNeedlesOligonucleotidesRatsSkinGlucoseOligonucleotides

Identifiers

PMID37395135
PMCPMC11875127
OpenAlexW4380634640

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.