Evidence map›Paper›PMID 37395102›Full record

ArticleCirculation research2023

Renin Cell Development: Insights From Chromatin Accessibility and Single-Cell Transcriptomics.

Alexandre G Martini, Jason P Smith, Silvia Medrano, Gal Finer, Nathan C Sheffield, Maria Luisa S Sequeira-Lopez, R Ariel Gomez

Abstract readLetter
In one paragraph

Article in Circulation research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Krüppel-like factor 2 regulates renin expression in mature juxtaglomerular cells.American journal of physiology. Renal physiology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alexandre G Martini *Departments of Pediatrics, Child Health Research Center (A.G.M., J.P.S., S.M., M.L.S.S.-L., R.A.G.), University of Virginia, Charlottesville.
Jason P Smith *Departments of Pediatrics, Child Health Research Center (A.G.M., J.P.S., S.M., M.L.S.S.-L., R.A.G.), University of Virginia, Charlottesville.ORCID 0000-0002-2688-0988
Silvia MedranoDepartments of Pediatrics, Child Health Research Center (A.G.M., J.P.S., S.M., M.L.S.S.-L., R.A.G.), University of Virginia, Charlottesville.ORCID 0000-0002-8516-0788
Gal FinerDivision of Nephrology, Ann and Robert H. Lurie Children's Hospital of Chicago, IL (G.F.).ORCID 0000-0002-1488-9985
Nathan C SheffieldCenter for Public Health Genomics (N.C.S.), University of Virginia, Charlottesville.ORCID 0000-0001-5643-4068
Maria Luisa S Sequeira-LopezDepartments of Pediatrics, Child Health Research Center (A.G.M., J.P.S., S.M., M.L.S.S.-L., R.A.G.), University of Virginia, Charlottesville.ORCID 0000-0002-4459-7940
R Ariel GomezDepartments of Pediatrics, Child Health Research Center (A.G.M., J.P.S., S.M., M.L.S.S.-L., R.A.G.), University of Virginia, Charlottesville.ORCID 0000-0002-5124-8255

Funding

Single-Cell Epigenomics, Transcriptomics, and Bioinformatics CoreP50DK096373 · NIDDK · UNIVERSITY OF VIRGINIA · PI ROBERTO Ariel GOMEZ · 2012 to 2026
$13.8M
Plasticity of renin cells in the kidney vasculatureR01DK116718 · NIDDK · UNIVERSITY OF VIRGINIA · PI GOMEZ, ROBERTO ARIEL · 2018 to 2022
$2.8M
Renin cell identity and blood pressure homeostasisR01HL148044 · NHLBI · UNIVERSITY OF VIRGINIA · PI SEQUEIRA-LOPEZ, MARIA LUISA SOLEDAD · 2020 to 2023
$2.7M
A modular data analysis ecosystem using portable encapsulated projectsR35GM128636 · NIGMS · UNIVERSITY OF VIRGINIA · PI SHEFFIELD, NATHAN · 2018 to 2022
$1.9M
Novel methods for large-scale genomic interval comparisonR01HG012558 · NHGRI · UNIVERSITY OF VIRGINIA · PI SHEFFIELD, NATHAN · 2022 to 2025
$1.8M
Fate of the kidney vasculature during partial neonatal ureteral obstructionR01DK116196 · NIDDK · UNIVERSITY OF VIRGINIA · PI SEQUEIRA-LOPEZ, MARIA LUISA SOLEDAD · 2018 to 2021
$1.5M
NHGRI NIH HHS R01 HG012558NHLBI NIH HHS R01 HL148044NIDDK NIH HHS P50 DK096373NIDDK NIH HHS R01 DK116196NIDDK NIH HHS R01 DK116718NIGMS NIH HHS R35 GM128636
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

ChromatinReninGene Expression ProfilingKidneySingle-Cell AnalysisTranscriptomeChromatinReninchromatinmesangial cellsperfusionpericytesrenintranscriptome

Identifiers

PMID37395102
PMCPMC10529662

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.