Evidence map›Paper›PMID 37395098›Full record

ArticleThe British journal of psychiatry : the journal of mental science2023

Brain serotonin 1A receptor binding: relationship to peripheral blood DNA methylation, recent life stress and childhood adversity in unmedicated major depression.

Hanga Galfalvy, Eileen Shea, Jacqueline de Vegvar, Spiro Pantazatos, Yung-Yu Huang, Ainsley K Burke, M Elizabeth Sublette, Maria A Oquendo, Francesca Zanderigo, Jeffrey M Miller and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The British journal of psychiatry : the journal of mental science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Brain serotonin, oxytocin, and their interaction: Relevance for eating disorders.Journal of psychopharmacology (Oxford, England) · 2025
    Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Hanga GalfalvyDepartment of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA; and Department of Biostatistics, Columbia University Mailman School of Public Health, New York, New York, USA.ORCID https://orcid.org/0000-0001-7156-6106
Eileen SheaUpward Farms, New York, New York, USA.
Jacqueline de VegvarDepartment of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.
Spiro PantazatosDepartment of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA; and Molecular Imaging and Neuropathology Area, New York State Psychiatric Institute, New York, New York, USA.
Yung-Yu HuangDepartment of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA; and Molecular Imaging and Neuropathology Area, New York State Psychiatric Institute, New York, New York, USA.
Ainsley K BurkeDepartment of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA; and Molecular Imaging and Neuropathology Area, New York State Psychiatric Institute, New York, New York, USA.
M Elizabeth SubletteDepartment of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA; and Molecular Imaging and Neuropathology Area, New York State Psychiatric Institute, New York, New York, USA.
Maria A OquendoPsychiatry Department, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Francesca ZanderigoDepartment of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA; and Molecular Imaging and Neuropathology Area, New York State Psychiatric Institute, New York, New York, USA.
Jeffrey M MillerDepartment of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA; and Molecular Imaging and Neuropathology Area, New York State Psychiatric Institute, New York, New York, USA.
J John MannDepartment of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA; Molecular Imaging and Neuropathology Area, New York State Psychiatric Institute, New York, New York, USA; and Department of Radiology, Columbia University, New York, New York, USA.ORCID https://orcid.org/0000-0002-0265-6586
New York Psychoanalytic Society and Institute · USColumbia University · USUniversity of Pennsylvania · US

Funding

Suicidal Behavior: Aggression Subtypes, Childhood Adversity and Stress ResponseP50MH090964 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI MANN, JOSEPH JOHN · 2013 to 2022
$23.6M
Neurobiology of Depression and AntidepressantsR01MH040695 · NIMH · WEILL MEDICAL COLLEGE OF CORNELL UNIV · PI MANN, JOSEPH JOHN · 1986 to 2014
$7.1M
NIMH NIH HHS P50 MH090964NIMH NIH HHS R01 MH040695
6 · The paper itself

Abstract

backgroundChildhood and lifetime adversity may reduce brain serotonergic (5-HT) neurotransmission by epigenetic mechanisms.

aimsWe tested the relationships of childhood adversity and recent stress to serotonin 1A (5-HT

methodMedication-free participants with MDD (

resultsRecent stress correlated positively with blood monocyte methylation at the -681 CpG site, adjusted for diagnosis, and had positive and region-specific correlations with 5-HT

conclusionsThese findings support a model in which recent stress increases 5-HT

Indexed as

Major Depressive DisorderBrainDepressionDNA MethylationFemaleHumansMalePositron-Emission TomographyReceptor, Serotonin, 5-HT1ASerotoninStress, PsychologicalReceptor, Serotonin, 5-HT1ASerotoninchildhood adversitymethylationPETSerotonin 1A receptorstress

Identifiers

PMID37395098
PMCPMC10514224
OpenAlexW4382919148

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.