Evidence map›Paper›PMID 37394032›Full record

ArticleJournal of molecular biology2023

Conformation-specific Synthetic Antibodies Discriminate Multiple Functional States of the Ion Channel CorA.

Satchal K Erramilli, Pawel K Dominik, Dawid Deneka, Piotr Tokarz, Sangwoo S Kim, Bharat G Reddy, Blazej M Skrobek, Olivier Dalmas, Eduardo Perozo, Anthony A Kossiakoff

Open access · greenAbstract read
In one paragraph

Article in Journal of molecular biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Conformational ensembles of the magnesium channel CorA reveal structural basis for channel gating.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Review
  3. Article
  4. Chaperone-assisted cryo-EM structure ofbioRxiv : the preprint server for biology · 2024
    Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 1 institution in 2 countries.

Satchal K ErramilliDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL, USA.
Pawel K DominikDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL, USA.
Dawid DenekaDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL, USA.
Piotr TokarzDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL, USA.
Sangwoo S KimDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL, USA.
Bharat G ReddyDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL, USA.
Blazej M SkrobekDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL, USA; Intercollegiate Faculty of Biotechnology of University of Gdansk and Medical University of Gdansk, Gdansk, Poland.
Olivier DalmasDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL, USA.
Eduardo PerozoDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL, USA; Grossman Institute for Neuroscience, Quantitative Biology and Human Behavior, The University of Chicago, Chicago, IL, USA.
Anthony A KossiakoffDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL, USA; Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, USA. Electronic address: koss@bsd.uchicago.edu.
University of Chicago · US

Funding

Chaperone-Assisted Structure Determination of Membrane ProteinsR01GM117372 · NIGMS · UNIVERSITY OF CHICAGO · PI ANTHONY A KOSSIAKOFF · 2016 to 2026
$4.0M
Structural basis of Mg2+ homeostasis - Equipment SupplementR01GM120561 · NIGMS · UNIVERSITY OF CHICAGO · PI PEROZO, EDUARDO A · 2017 to 2020
$1.4M
NIGMS NIH HHS R01 GM117372NIGMS NIH HHS R01 GM120561
6 · The paper itself

Abstract

CorA, the primary magnesium ion channel in prokaryotes and archaea, is a prototypical homopentameric ion channel that undergoes ion-dependent conformational transitions. CorA adopts five-fold symmetric non-conductive states in the presence of high concentrations of Mg

Indexed as

AntibodiesBacterial ProteinsCation Transport ProteinsIon ChannelsMagnesiumProtein ConformationAntibodiesBacterial ProteinsCation Transport ProteinsIon ChannelsMagnesiumCorAion channelmembrane proteinssynthetic antibodiesX-ray crystallography

Identifiers

PMID37394032
PMCPMC10529903
OpenAlexW4382651928

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.