Evidence map›Paper›PMID 37394028›Full record

ArticleEuropean journal of pharmacology2023

Regional characterisation of TRPV1 and TRPA1 signalling in the mouse colon mucosa.

Caryl Evans, Kathryn Howells, Rie Suzuki, Alastair J H Brown, Helen M Cox

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of pharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Caryl EvansKing's College London, Wolfson Centre for Age-Related Diseases, Institute of Psychology, Psychiatry and Neuroscience, Hodgkin Building, Guy's Campus, London, SE1 1UL, UK. Electronic address: caryl.evans@kcl.ac.uk.
Kathryn HowellsNorthern General Hospital, Herries Road, Sheffield, S5 7AU, UK.
Rie SuzukiHeptares Therapeutics Ltd, Steinmetz Building, Granta Park, Great Abington, Cambridge, CB21 6DG, UK.
Alastair J H BrownHeptares Therapeutics Ltd, Steinmetz Building, Granta Park, Great Abington, Cambridge, CB21 6DG, UK.
Helen M CoxKing's College London, Wolfson Centre for Age-Related Diseases, Institute of Psychology, Psychiatry and Neuroscience, Hodgkin Building, Guy's Campus, London, SE1 1UL, UK.
Heptares Therapeutics (United Kingdom) · GBKing's College London · GBNorthern General Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Capsaicin and allyl isothiocyanate (AITC) activate transient receptor potential (TRP) vanilloid-1 (TRPV1) and TRP ankyrin-1 (TRPA1), respectively. TRPV1 and TRPA1 expression have been identified in the gastrointestinal (GI) tract. GI mucosal functions remain largely undefined for TRPV1 and TRPA1 with side-dependence and regional differences in signalling unclear. Here we investigated TRPV1- and TRPA1-induced vectorial ion transport as changes in short-circuit current (ΔI

Indexed as

Transient Receptor Potential ChannelsAnimalsCapsaicinColonIsothiocyanatesMiceMucous MembraneTetrodotoxinTRPA1 Cation ChannelTRPV Cation Channels2,3,4-tri-O-acetylarabinopyranosyl isothiocyanateallyl isothiocyanateCapsaicinIsothiocyanatesTetrodotoxinTransient Receptor Potential ChannelsTRPA1 Cation ChannelTRPV1 protein, mouseTRPV Cation ChannelsGastrointestinal regional specificityMucosal ion transportTRPA1TRPV1

Identifiers

PMID37394028
PMCPMC10847397
OpenAlexW4382655272

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.