Evidence map›Paper›PMID 37394004›Full record

ArticleThe Journal of biological chemistry2023

The battle for silver binding: How the interplay between the SilE, SilF, and SilB proteins contributes to the silver efflux pump mechanism.

Cyrielle Arrault, Yoan Rocky Monneau, Marie Martin, François-Xavier Cantrelle, Emmanuelle Boll, Fabien Chirot, Clothilde Comby Zerbino, Olivier Walker, Maggy Hologne

Open access · goldAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 11 citations in OpenAlex.

  1. Experimental evolution ofMicrobiology spectrum · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Cyrielle ArraultUniversité de Lyon, CNRS, UCB Lyon1, Institut des Sciences Analytiques, UMR5280, Villeurbanne, France.
Yoan Rocky MonneauUniversité de Lyon, CNRS, UCB Lyon1, Institut des Sciences Analytiques, UMR5280, Villeurbanne, France; Department of Structural Biology, St Jude Children's Research Hospital, Memphis, Tennessee, USA.
Marie MartinUniversité de Lyon, CNRS, UCB Lyon1, Institut des Sciences Analytiques, UMR5280, Villeurbanne, France.
François-Xavier CantrelleUniversité de Lille, CNRS, UMR8576 - UGSF - Unité de Glycobiologie Structurale et Fonctionnelle, Lille, France.
Emmanuelle BollUniversité de Lille, CNRS, UMR8576 - UGSF - Unité de Glycobiologie Structurale et Fonctionnelle, Lille, France.
Fabien ChirotUniv Lyon 1, Université Claude Bernard Lyon 1, CNRS, Institut Lumière Matière, UMR5306, Cité Lyonnaise de l'Environnement et de l'Analyse, Villeurbanne, France.
Clothilde Comby ZerbinoUniv Lyon 1, Université Claude Bernard Lyon 1, CNRS, Institut Lumière Matière, UMR5306, Cité Lyonnaise de l'Environnement et de l'Analyse, Villeurbanne, France.
Olivier WalkerUniversité de Lyon, CNRS, UCB Lyon1, Institut des Sciences Analytiques, UMR5280, Villeurbanne, France.
Maggy HologneUniversité de Lyon, CNRS, UCB Lyon1, Institut des Sciences Analytiques, UMR5280, Villeurbanne, France. Electronic address: maggy.hologne@univ-lyon1.fr.
Université Claude Bernard Lyon 1 · FRCentre National de la Recherche Scientifique · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The resistance of gram-negative bacteria to silver ions is mediated by a silver efflux pump, which mainly relies on a tripartite efflux complex SilCBA, a metallochaperone SilF and an intrinsically disordered protein SilE. However, the precise mechanism by which silver ions are extruded from the cell and the different roles of SilB, SilF, and SilE remain poorly understood. To address these questions, we employed nuclear magnetic resonance and mass spectrometry to investigate the interplay between these proteins. We first solved the solution structures of SilF in its free and Ag

Indexed as

SilverBiological TransportIonsMembrane Transport ProteinsIonsMembrane Transport ProteinsSilvermetal ion–protein interactionNMRprotein–protein interactionprotein structurestructural biologystructural model

Identifiers

PMID37394004
PMCPMC10407283
OpenAlexW4382798115

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.