Evidence map›Paper›PMID 37393619›Full record

ArticleCell reports2023

Cytosolic LPS-induced caspase-11 oligomerization and activation is regulated by extended synaptotagmin 1.

Yilei Ma, Ru Zhao, Hui Guo, Qingchao Tong, Wallace Y Langdon, Weiwei Liu, Jun Zhang, Jian Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Yilei MaDepartment of Clinical Laboratory, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, P.R. China; Department of Pathology, The University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, IA 52242, USA; Key Laboratory of Precision Medicine in Diagnosis and Monitoring Research of Zhejiang Province, Hangzhou, Zhejiang, P.R. China. Electronic address: 3316045@zju.edu.cn.
Ru ZhaoDepartment of Clinical Laboratory, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, P.R. China; Key Laboratory of Precision Medicine in Diagnosis and Monitoring Research of Zhejiang Province, Hangzhou, Zhejiang, P.R. China.
Hui GuoDepartment of Pathology, The University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, IA 52242, USA.
Qingchao TongDepartment of Clinical Laboratory, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, P.R. China; Key Laboratory of Precision Medicine in Diagnosis and Monitoring Research of Zhejiang Province, Hangzhou, Zhejiang, P.R. China.
Wallace Y LangdonSchool of Biomedical Sciences, University of Western Australia, Perth, WA, Australia.
Weiwei LiuDepartment of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44106, USA.
Jun ZhangDepartment of Clinical Laboratory, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, P.R. China; Key Laboratory of Precision Medicine in Diagnosis and Monitoring Research of Zhejiang Province, Hangzhou, Zhejiang, P.R. China. Electronic address: jameszhang2000@zju.edu.cn.
Jian ZhangDepartment of Pathology, The University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, IA 52242, USA. Electronic address: jian-zhang@uiowa.edu.
Sir Run Run Shaw Hospital · CNZhejiang University · CNCleveland Clinic Lerner College of Medicine · USThe University of Western Australia · AUUniversity of Iowa · US

Funding

NEDD4 IN T HELPER CELL DEVELOPMENT AND AUTOIMMUNITYR01AI090901 · NIAID · UNIVERSITY OF IOWA · PI WALDSCHMIDT, THOMAS J · 2010 to 2020
$4.0M
Regulation of Innate Immune System Sensing of C. Albicans InfectionsR01AI123253 · NIAID · UNIVERSITY OF IOWA · PI WALDSCHMIDT, THOMAS J · 2016 to 2020
$2.1M
Role of Protein Ubiquitination in SepsisR01AI121196 · NIAID · UNIVERSITY OF IOWA · PI ZHANG, JIAN · 2016 to 2020
$1.7M
NIAID NIH HHS R01 AI090901NIAID NIH HHS R01 AI121196NIAID NIH HHS R01 AI123253
6 · The paper itself

Abstract

Caspase-11 (Casp-11) is known to induce pyroptosis and defends against cytosol-invading bacterial pathogens, but its regulation remains poorly defined. Here, we identified extended synaptotagmin 1 (E-Syt1), an endoplasmic reticulum protein, as a key regulator of Casp-11 oligomerization and activation. Macrophages lacking E-Syt1 exhibited reduced production of interleukin-1β (IL-1β) and impaired pyroptosis upon cytosolic lipopolysaccharide (LPS) delivery and cytosol-invasive bacterial infection. Moreover, cleavage of Casp-11 and its downstream substrate gasdermin D were significantly diminished in ESyt1

Indexed as

CaspasesLipopolysaccharidesAnimalsCaspase 1Caspases, InitiatorCytosolInflammasomesMacrophagesMiceSynaptotagmin ICasp4 protein, mouseCaspase 1CaspasesCaspases, InitiatorInflammasomesLipopolysaccharidesSynaptotagmin ISyt1 protein, mousecaspase-11CP: Cell biologyCP: ImmunologyendotoxemiaE-Syt1host defenseoligomerizationpyroptosis

Identifiers

PMID37393619
PMCPMC10528594
OpenAlexW4382794409

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.