Evidence map›Paper›PMID 37393564›Full record

ArticleEpigenetics2023

Biological stability of DNA methylation measurements over varying intervals of time and in the presence of acute stress.

Abner T Apsley, Qiaofeng Ye, Laura Etzel, Sarah Wolf, Waylon J Hastings, Brooke C Mattern, Sue Rutherford Siegel, Idan Shalev

Open access · diamondAbstract read
In one paragraph

Article in Epigenetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Review
  3. Acute stress induces changes in epigenome-wide DNA methylation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Longitudinal Analysis of PlacentalInternational journal of molecular sciences · 2025
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Abner T ApsleyDepartment of Biobehavioral Health, The Pennsylvania State University, University Park, PA, USA.ORCID 0000-0003-3420-7491
Qiaofeng YeDepartment of Biobehavioral Health, The Pennsylvania State University, University Park, PA, USA.
Laura EtzelDepartment of Biobehavioral Health, The Pennsylvania State University, University Park, PA, USA.
Sarah WolfDepartment of Biobehavioral Health, The Pennsylvania State University, University Park, PA, USA.
Waylon J HastingsDepartment of Psychiatry, Tulane University School of Medicine, New Orleans, LA, USA.
Brooke C MatternDepartment of Biobehavioral Health, The Pennsylvania State University, University Park, PA, USA.
Sue Rutherford SiegelDepartment of Biobehavioral Health, The Pennsylvania State University, University Park, PA, USA.
Idan ShalevDepartment of Biobehavioral Health, The Pennsylvania State University, University Park, PA, USA.ORCID 0000-0003-0773-4835
Pennsylvania State University · USTulane University · US

Funding

Penn State Clinical and Translational Science InstituteUL1TR002014 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KRASCHNEWSKI, JENNIFER L. · 2016 to 2025
$33.7M
Psychosocial Determinants and Biological Pathway to Healthy Aging (Pathways)T32AG049676 · NIA · PENNSYLVANIA STATE UNIVERSITY, THE · PI LYNN M. MARTIRE · 2016 to 2026
$3.9M
Elucidating the measurement of telomeres: Development of a transdisciplinary, high-impact Telomere Research NetworkU24AG066528 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI DRURY, STACY SCHMIDT · 2019 to 2023
$3.0M
Temporal Genomics Mechanisms Underlying Disease and AgingR21AG055621 · NIA · PENNSYLVANIA STATE UNIVERSITY, THE · PI SHALEV, IDAN · 2018 to 2019
$436k
NCATS NIH HHS UL1 TR002014NIA NIH HHS R21 AG055621NIA NIH HHS T32 AG049676NIA NIH HHS U24 AG066528
6 · The paper itself

Abstract

Identifying factors that influence the stability of DNA methylation measurements across biological replicates is of critical importance in basic and clinical research. Using a within-person between-group experimental design (

Indexed as

DNA MethylationStress, PsychologicalAgingEpigenesis, GeneticGenomicsTime Factorsacute psychosocial stressDNA methylationearly-life adversityepigenetic clocksimmune cell estimatorsstabilitytemporal dynamics

Identifiers

PMID37393564
PMCPMC10316737
OpenAlexW4382893802

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.