Evidence map›Paper›PMID 37393496›Full record

ArticleJournal of Alzheimer's disease : JAD2023

Associations Between Parity and Cognition: Race/Ethnic Differences.

Carlos E E Araujo-Menendez, Ursula G Saelzler, Ariana M Stickel, Erin E Sundermann, Sarah J Banks, Andrea Paipilla, McKinna L Barnes, Matthew S Panizzon

Open access · bronzeAbstract read
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Carlos E E Araujo-MenendezDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Ursula G SaelzlerDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Ariana M StickelDepartment of Psychology, San Diego State University, La Jolla, CA, USA.
Erin E SundermannDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Sarah J BanksDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Andrea PaipillaDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
McKinna L BarnesDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Matthew S PanizzonDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
University of California San Diego · USSan Diego State University · US

Funding

UCSD Shiley-Marcos Alzheimer's Disease Research Center P30P30AG062429 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JAMES B BREWER · 2019 to 2026
$34.9M
SDSU FUERTE: Recognition of Excellence in DEIA and Mentorship in support of Faculty SuccessU54CA267789 · NCI · SAN DIEGO STATE UNIVERSITY · PI Eileen Virtusio Pitpitan · 2021 to 2026
$15.5M
Sex-specific cognitive expression and risk in preclinical Alzheimer's diseaseR01AG066088 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BANKS, SARAH · 2019 to 2023
$3.9M
Sex Differences in the Clinical Expression of Alzheimer's Disease Neuropathology and Their Underlying Biological MechanismsR01AG074221 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUNDERMANN, ERIN ELIZABETH · 2021 to 2025
$2.7M
Risk Factors for Alzheimer's Disease Among Latinos: Relationships Between Cardiovascular Disease Risk, Acculturation, Small Vessel Disease, and Alzheimer's BiomarkersK08AG075351 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ariana Stickel · 2022 to 2026
$770k
Understanding the relationship between female reproductive span and dementia riskR21AG074212 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PANIZZON, MATTHEW S · 2021 to 2022
$464k
NCI NIH HHS U54 CA267789NIA NIH HHS K08 AG075351NIA NIH HHS L30 AG074401NIA NIH HHS P30 AG062429NIA NIH HHS R01 AG066088NIA NIH HHS R01 AG074221NIA NIH HHS R21 AG074212
6 · The paper itself

Abstract

backgroundRace/ethnicity is associated with differences in reproductive history and cognition individually, yet it remains an understudied factor in the relationship between parity and later-life cognition.

objectiveTo evaluate if the association between parity and cognition differs between racial/ethnic groups.

methodsParticipants included 778 older, postmenopausal women from the Health and Nutrition Examination Survey (Latina: n = 178, Non-Latino Black [NLB]: n = 169, Non-Latino White [NLW]: n = 431) who self-reported at least one birth. Cognitive outcomes included working memory, learning memory, and verbal fluency. Covariates included age, education, cardiovascular and other reproductive health factors, adult socioeconomic status (SES) and depressive symptoms. We fit a series of linear models to examine a) whether parity was associated with cognitive functioning, b) if this association varied by race/ethnicity through parity by race/ethnicity interactions, and c) individual parity with cognition associations stratified by race/ethnicity.

resultsIn the full sample, parity was significantly negatively associated with Digit Symbol Substitution Test (DSST) performance (b = -0.70, p = 0.024) but not Animal Fluency or word-list learning and memory. Tests of race/ethnicity-by-parity interactions were not statistically significant (ps > 0.05). However, stratified analyses by race/ethnicity showed a differential effect of parity on DSST performance, such that parity was significantly negatively associated with DSST performance (b = -1.66, p = 0.007) among Latinas but not in NLWs (b = -0.16, p = 0.74) or NLBs (b = -0.81, p = 0.191).

conclusionAmong Latina, but not NLB or NLW women, greater parity was associated with worse processing speed/executive functioning later in life. Further research is needed to understand the mechanisms driving racial/ethnic differences.

Indexed as

CognitionEthnicityParityAgedBlack or African AmericanCognition DisordersFemaleHispanic or LatinoHumansPostmenopauseRacial GroupsWhiteAlzheimer’s diseasecognitioncross-cultural researchpregnancyreproductive health

Identifiers

PMID37393496
PMCPMC10473123
OpenAlexW4382242259

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.