Evidence map›Paper›PMID 37393263›Full record

ArticleJournal of eating disorders2023

Low bone mineral density is found in low weight female youth with avoidant/restrictive food intake disorder and associated with higher PYY levels.

Aluma Chovel Sella, Kendra R Becker, Meghan Slattery, Kristine Hauser, Elisa Asanza, Casey Stern, Megan Kuhnle, Nadia Micali, Kamryn T Eddy, Madhusmita Misra and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of eating disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. The role of PYY in improving insulin resistance.Frontiers in endocrinology · 2026
    Review
  4. Article
  5. Avoidant/Restrictive Food Intake Disorder: Review and Recent Advances.Focus (American Psychiatric Publishing) · 2024
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Aluma Chovel SellaNeuroendocrine Unit, Massachusetts General Hospital, 55 Fruit St., Boston, MA, 02114, USA.
Kendra R BeckerEating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston, MA, USA.
Meghan SlatteryNeuroendocrine Unit, Massachusetts General Hospital, 55 Fruit St., Boston, MA, 02114, USA.
Kristine HauserNeuroendocrine Unit, Massachusetts General Hospital, 55 Fruit St., Boston, MA, 02114, USA.
Elisa AsanzaNeuroendocrine Unit, Massachusetts General Hospital, 55 Fruit St., Boston, MA, 02114, USA.
Casey SternEating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston, MA, USA.
Megan KuhnleNeuroendocrine Unit, Massachusetts General Hospital, 55 Fruit St., Boston, MA, 02114, USA.
Nadia MicaliGreat Ormond Street Institute of Child Health, University College London, London, UK.
Kamryn T EddyEating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston, MA, USA.
Madhusmita Misra *Neuroendocrine Unit, Massachusetts General Hospital, 55 Fruit St., Boston, MA, 02114, USA.
Jennifer J Thomas *Eating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston, MA, USA.
Elizabeth A Lawson *Neuroendocrine Unit, Massachusetts General Hospital, 55 Fruit St., Boston, MA, 02114, USA. ealawson@mgh.harvard.edu.

Funding

Neurobiology of avoidant/restrictive eating in youthK24MH120568 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI LAWSON, ELIZABETH AUSTEN · 2019 to 2023
$961k
NIMH NIH HHS K24 MH120568
6 · The paper itself

Abstract

backgroundAvoidant/restrictive food intake disorder (ARFID) is a restrictive eating disorder commonly associated with medical complications of undernutrition and low weight. In adolescence, a critical time for bone accrual, the impact of ARFID on bone health is uncertain. We aimed to study bone health in low-weight females with ARFID, as well as the association between peptide YY (PYY), an anorexigenic hormone with a role in regulation of bone metabolism, and bone mineral density (BMD) in these individuals. We hypothesized that BMD would be lower in low-weight females with ARFID than healthy controls (HC), and that PYY levels would be negatively associated with BMD.

methodsWe performed a cross-sectional study in 14 adolescent low-weight females with ARFID and 20 HC 10-23 years old. We assessed BMD (total body, total body less head and lumbar spine) using dual x-ray absorptiometry (DXA) and assessed fasting total PYY concentration in blood.

resultsTotal body BMD Z-scores were significantly lower in ARFID than in HC (- 1.41 ± 0.28 vs. - 0.50 ± 0.25, p = 0.021). Mean PYY levels trended higher in ARFID vs. HC (98.18 ± 13.55 pg/ml vs. 71.40 ± 5.61 pg/ml, p = 0.055). In multivariate analysis within the ARFID group, PYY was negatively associated with lumbar BMD adjusted for age (β = -0.481, p = 0.032).

conclusionOur findings suggest that female adolescents with low-weight ARFID may have lower BMD than healthy controls and that higher PYY levels may be associated with lower BMD at some, but not all, sites in ARFID. Further research with larger samples will be important to investigate whether high PYY drives bone loss in ARFID.

Indexed as

AdolescenceARFIDAvoidant/restrictive food intake disorderBMDBone healthBone mineral DensityDXAFeeding and eating disorderLow weightPYY

Identifiers

PMID37393263
PMCPMC10315026

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.