Evidence map›Paper›PMID 37393198›Full record

ArticleLangenbeck's archives of surgery2023

Converting a probe-based fluorescence system into an easy-to-use adjunct for the detection of parathyroid glands accidentally resected intraoperatively.

Wei Chen, Ru Zhang, Ruijie Yang, Jie Hu, John E Phay, Peng Liu, Xiaopeng Ma, Ronald X Xu

Abstract read
PubMed Publisher
In one paragraph

Article in Langenbeck's archives of surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Wei Chen *Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei, 230026, China.ORCID http://orcid.org/0000-0003-3921-3305
Ru Zhang *Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei, 230026, China.
Ruijie YangDepartment of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei, 230026, China.
Jie HuDepartment of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei, 230026, China.
John E PhayDepartment of Surgery, Ohio State University Comprehensive Cancer Center and Ohio State University Wexner Medical Center, 410 W 10Th Ave, Columbus, OH, 43210, USA.
Peng LiuSuzhou Institute for Advanced Research, University of Science and Technology of China, Renai Road. NO. 188, Suzhou Industrial Park, Suzhou, 215123, Jiangsu Province, China.ORCID http://orcid.org/0000-0003-3873-247X
Xiaopeng MaFirst Affiliated Hospital, University of Science and Technology of China, Hefei, 230031, China.ORCID http://orcid.org/0000-0002-3517-5439
Ronald X XuDepartment of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei, 230026, China. xux@ustc.edu.cn.ORCID http://orcid.org/0000-0003-2486-5677
University of Science and Technology of China · CNSuzhou University of Science and Technology · CNThe Ohio State University Wexner Medical Center · US

Funding

the Fundamental Research Funds for the Central Universities WK9110000151the National Key R&D Program of China 2021YFC2401402the Strategic Priority Research Program of the Chinese Academy of Sciences XDA16021303
6 · The paper itself

Abstract

purposeThe reported threshold of a near-infrared fluorescence detection probe (FDP) for judging parathyroid glands (PGs) is based on the autofluorescence intensity relative to other non-PG tissues, making it unreliable when not enough reference tissues are measured. We aim to convert FDP into a more convenient tool for identifying accidentally resected PGs by quantitative measurements of autofluorescence in resected tissues.

methodsIt was a prospective study approved by the Institutional Review Board. The research was divided into two stages: (1) In order to calibrate the novel FDP system, autofluorescence intensity of different in / ex vivo tissues was measured and the optimal threshold was obtained using receiver operating characteristic (ROC) curve. (2) To further validate the effectiveness of the new system, detection rates of incidental resected PGs by pathology in the control group and by FDP in the experimental group were compared.

resultsAutofluorescence of PGs was significantly higher than that of non-PG tissue (43 patients, Mann-Whitney U test, p < 0.0001). An optimal threshold of sensitivity / specificity (78.8% and 85.1%) for discriminating PGs was obtained. The detection rates of experimental group (20 patients) and control group (33 patients) are 5.0% and 6.1% respectively (one-tailed Fisher's exact test, p = 0.6837), indicating the novel FDP system can achieve a similar proportion of PG detection compared with pathological examinations.

conclusionsThe novel FDP system can be used as an easy-to-use adjunct for detecting PG accidentally resected intraoperatively before the tissues are sent for frozen sections during thyroidectomy surgeries.

trial registrationRegistration number: ChiCTR2200057957.

Indexed as

Parathyroid GlandsThyroidectomyHumansProspective StudiesROC CurveStatistics, NonparametricAutofluorescenceNear-infraredParathyroid gland

Identifiers

PMID37393198
OpenAlexW4382798581

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.