Evidence map›Paper›PMID 37392972›Full record

ArticleMucosal immunology2023

Increased innate immune activation induces protective RSV-specific lung-resident memory T cells in neonatal mice.

Allison M W Malloy, Zhongyan Lu, Margaret Kehl, Jarina Pena DaMata, Annie W Lau-Kilby, Mathilde Turfkruyer

Open access · hybridAbstract read
In one paragraph

Article in Mucosal immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Allison M W MalloyLaboratory of Infectious Diseases and Host Defense, Department of Pediatrics, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, USA. Electronic address: allison.malloy@usuhs.edu.
Zhongyan LuLaboratory of Infectious Diseases and Host Defense, Department of Pediatrics, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, USA.
Margaret KehlLaboratory of Infectious Diseases and Host Defense, Department of Pediatrics, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, USA.
Jarina Pena DaMataLaboratory of Infectious Diseases and Host Defense, Department of Pediatrics, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, USA.
Annie W Lau-KilbyLaboratory of Infectious Diseases and Host Defense, Department of Pediatrics, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, USA.
Mathilde TurfkruyerLaboratory of Infectious Diseases and Host Defense, Department of Pediatrics, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, USA.
Henry M. Jackson Foundation · USUniformed Services University of the Health Sciences · US

Funding

Respiratory mucosal immune development in early life and the quest for protective local memory against respiratory syncytial virus.R01AI154619 · NIAID · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI MALLOY, ALLISON MARIE WAHL · 2020 to 2023
$1.4M
NIAID NIH HHS R01 AI154619
6 · The paper itself

Abstract

Young infants frequently experience respiratory tract infections, yet vaccines designed to provide mucosal protection are lacking. Localizing pathogen-specific cellular and humoral immune responses to the lung could provide improved immune protection. We used a well-characterized murine model of respiratory syncytial virus (RSV) to study the development of lung-resident memory T cells (T

Indexed as

Animals, NewbornAntigens, CDImmunity, InnateLungMemory T CellsRespiratory Syncytial VirusesRespiratory Syncytial Virus InfectionsAnimalsAntigens, Differentiation, T-LymphocyteCD69 AntigensCD8-Positive T-LymphocytesDisease Models, AnimalHumansImmunologic MemoryIntegrin alpha ChainsLectins, C-Typealpha E integrinsAntigens, CDAntigens, Differentiation, T-LymphocyteCD69 AntigensIntegrin alpha ChainsLectins, C-Type

Identifiers

PMID37392972
PMCPMC13343346
OpenAlexW4382890582

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.