Evidence map›Paper›PMID 37392292›Full record

ArticleStem cell reviews and reports2023

Keratose Hydrogel Drives Differentiation of Cardiac Vascular Smooth Muscle Progenitor Cells: Implications in Ischemic Treatment.

Benjamin T Ledford, Miao Chen, Mark Van Dyke, Catherine Barron, Xiaonan Zhang, Aurora Cartaya, Youjing Zheng, Ahmet Ceylan, Aaron Goldstein, Jia-Qiang He

Open access · hybridAbstract read
PubMed Publisher
In one paragraph

Article in Stem cell reviews and reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Heart-derived endogenous stem cells.Molecular biology reports · 2025
    Review
  2. Degradation of the α-Carboxyl Terminus 11 Peptide:ACS pharmacology & translational science · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Benjamin T Ledford *Department of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, 24061, USA.
Miao Chen *Department of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, 24061, USA.
Mark Van DykeDepartment of Biomedical Engineering, College of Engineering, University of Arizona, Tucson, AZ, 85721, USA.
Catherine BarronDepartment of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, 24061, USA.
Xiaonan ZhangBeijing Yulong Shengshi Biotechnology, Haidian District, Beijing, 100085, China.
Aurora CartayaDepartment of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, 24061, USA.
Youjing ZhengDepartment of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, 24061, USA.
Ahmet CeylanDepartment of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, 24061, USA.
Aaron GoldsteinDepartment of Chemical Engineering, School of Biomedical Engineering and Sciences, Virginia Tech, Blacksburg, VA, 24061, USA.
Jia-Qiang HeDepartment of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, 24061, USA. jiahe@vt.edu.ORCID 0000-0002-0640-5960
Virginia–Maryland College of Veterinary Medicine · USUniversity of Arizona · USVirginia Tech · US

Funding

Edward Via College of Osteopathic Medicine PJ6SPVHJInstitute for Critical Technologies and Applied Science, Virginia Tech JFC2014_JIAHE958451025Virginia-Maryland College of Veterinary Medicine 118995Virginia's Commonwealth Health Research Board 208-09-16JHE
6 · The paper itself

Abstract

Peripheral artery disease (PAD) is a common vascular disorder in the extremity of limbs with limited clinical treatments. Stem cells hold great promise for the treatment of PAD, but their therapeutic efficiency is limited due to multiple factors, such as poor engraftment and non-optimal selection of cell type. To date, stem cells from a variety of tissue sources have been tested, but little information is available regarding vascular smooth muscle cells (VSMCs) for PAD therapy. The present study examines the effects of keratose (KOS) hydrogels on c-kit

Indexed as

Cell DifferentiationHydrogelsIschemiaMuscle, Smooth, VascularStem CellsAnimalsHindlimbMaleMiceMice, Inbred C57BLMyocytes, Smooth MusclePeripheral Arterial DiseaseStem Cell TransplantationTransforming Growth Factor beta1HydrogelsTransforming Growth Factor beta1c-kit+/CD31− cardiac vascular smooth muscle progenitor cellsKeratinKeratose hydrogelMouse hindlimb ischemiaTGF-β1Vascular smooth muscle cells

Identifiers

PMID37392292
OpenAlexW4382810858

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.