Evidence map›Paper›PMID 37392270›Full record

ArticleAIDS and behavior2023

Acceptability of a Combination Adherence Strategy to Support HIV Antiretroviral Therapy and Pre-exposure Prophylaxis Adherence During Pregnancy and Breastfeeding in Malawi.

Friday Saidi, Twambilile Phanga, Lauren A Graybill, Katie R Mollan, Lauren M Hill, Watson Sibande, Getrude Msowoya, Annie Thom, Nora E Rosenberg, Kellie Freeborn and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in AIDS and behavior, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Friday SaidiUniversity of North Carolina (UNC) Project Malawi, Bag A-104, Lilongwe, Malawi. fsaidi@unclilongwe.org.ORCID http://orcid.org/0000-0003-1190-1499
Twambilile PhangaUniversity of North Carolina (UNC) Project Malawi, Bag A-104, Lilongwe, Malawi.
Lauren A GraybillDepartment of Epidemiology, University of North Carolina at Chapel Hill Gillings School of Global Public Health, Chapel Hill, NC, USA.
Katie R MollanDepartment of Epidemiology, University of North Carolina at Chapel Hill Gillings School of Global Public Health, Chapel Hill, NC, USA.
Lauren M HillDepartment of Health Behavior, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Watson SibandeUniversity of North Carolina (UNC) Project Malawi, Bag A-104, Lilongwe, Malawi.
Getrude MsowoyaUniversity of North Carolina (UNC) Project Malawi, Bag A-104, Lilongwe, Malawi.
Annie ThomUniversity of North Carolina (UNC) Project Malawi, Bag A-104, Lilongwe, Malawi.
Nora E RosenbergDepartment of Health Behavior, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Kellie FreebornDepartment of Obstetrics and Gynecology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
K Rivet AmicoDepartment of Health Behavior and Health Education, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Sam PhiriPartners in Hope, Lilongwe, Malawi.
Wilbroad MutaleDepartment of Health Policy, University of Zambia School of Public Health, Lusaka, Zambia.
Benjamin H ChiDepartment of Obstetrics and Gynecology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Funding

Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
UJMT – ORWH – Gazzetta, Issa-BoubeD43TW009340 · FIC · UNIV OF NORTH CAROLINA CHAPEL HILL · PI William Checkley, Benjamin H. Chi · 2017 to 2026
$14.8M
Malawi HIV Implementation Research Scientist Training Program (MHIRST)D43TW010060 · FIC · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MINA CHRISTINE HOSSEINIPOUR, Victor Mwapasa · 2015 to 2026
$3.8M
A dyad approach to combination HIV prevention in pregnancy for Zambia and MalawiR01AI131060 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CHI, BENJAMIN H., MUTALE, WILBROAD · 2017 to 2020
$2.7M
Mentoring new investigators in PMTCT implementation researchK24AI120796 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Benjamin H. Chi · 2016 to 2026
$1.3M
Promoting PrEP shared decision-making and adherence among pregnant and breastfeeding women in ZambiaK01MH121186 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HILL, LAUREN · 2020 to 2024
$906k
FIC NIH HHS D43 TW009340FIC NIH HHS D43 TW010060NIAID NIH HHS K24 AI120796NIAID NIH HHS P30 AI050410NIAID NIH HHS R01 AI131060NIMH NIH HHS K01 MH121186
6 · The paper itself

Abstract

In two parallel pilot studies, we implemented a combination adherence intervention of patient-centered counselling and adherence supporter training, tailored to support HIV treatment (i.e., antiretroviral therapy) or prevention (i.e., pre-exposure prophylaxis, or PrEP) during pregnancy and breastfeeding. Using a mixed-methods approach, we evaluated the intervention's acceptability. We investigated engagement, satisfaction, and discussion content via survey to all 151 participants assigned to the intervention arm (51 women living with HIV, 100 PrEP-eligible women without HIV). We also conducted serial in-depth interviews with a subgroup (n = 40) at enrollment, three months, and six months. In the quantitative analysis, the vast majority reported high satisfaction with intervention components and expressed desire to receive it in the future, if made available. These findings were supported in the qualitative analysis, with favorable comments about counselor engagement, intervention content and types of support received from adherence supporters. Overall, these results demonstrate high acceptability and provide support for HIV status-neutral interventions for antiretroviral adherence.

Indexed as

HIV InfectionsPre-Exposure ProphylaxisAnti-Retroviral AgentsBreast FeedingFemaleHumansMalawiPregnancyAnti-Retroviral AgentsAntiretroviral drugsHIVMixed methodsPre-exposure prophylaxisPregnancy and breastfeeding

Identifiers

PMID37392270

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.