Evidence map›Paper›PMID 37392222›Full record

ArticleCellular and molecular life sciences : CMLS2023

The normalizing effects of the CYP46A1 activator efavirenz on retinal sterol levels and risk factors for glaucoma in Apoj

Nicole El-Darzi, Natalia Mast, Yong Li, Brian Dailey, Min Kang, Douglas J Rhee, Irina A Pikuleva

Open access · hybridAbstract read
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Nicole El-DarziDepartment of Ophthalmology and Visual Science, Case Western Reserve University, Cleveland, OH, 44106, USA.ORCID http://orcid.org/0000-0003-2103-9492
Natalia MastDepartment of Ophthalmology and Visual Science, Case Western Reserve University, Cleveland, OH, 44106, USA.ORCID http://orcid.org/0000-0001-6427-640X
Yong LiDepartment of Ophthalmology and Visual Science, Case Western Reserve University, Cleveland, OH, 44106, USA.
Brian DaileyDepartment of Ophthalmology and Visual Science, Case Western Reserve University, Cleveland, OH, 44106, USA.ORCID http://orcid.org/0000-0001-7898-321X
Min KangDepartment of Ophthalmology and Visual Science, Case Western Reserve University, Cleveland, OH, 44106, USA.
Douglas J RheeDepartment of Ophthalmology and Visual Science, Case Western Reserve University, Cleveland, OH, 44106, USA.
Irina A PikulevaDepartment of Ophthalmology and Visual Science, Case Western Reserve University, Cleveland, OH, 44106, USA. iap8@case.edu.ORCID http://orcid.org/0000-0001-9742-6232
Case Western Reserve University · US

Funding

TISSUE CULTURE AND HYBRIDOMA MODULEP30EY011373 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI Irina A Pikuleva · 1997 to 2026
$17.7M
Significance of CYP46A1 and other P450s in retinal functionR01EY018383 · NEI · UNIVERSITY OF TEXAS MED BR GALVESTON · PI PIKULEVA, IRINA A · 2007 to 2024
$6.8M
NEI NIH HHS EY011373NEI NIH HHS EY018383NEI NIH HHS P30 EY011373NEI NIH HHS R01 EY018383
6 · The paper itself

Abstract

Apolipoprotein J (APOJ) is a multifunctional protein with genetic evidence suggesting an association between APOJ polymorphisms and Alzheimer's disease as well as exfoliation glaucoma. Herein we conducted ocular characterizations of Apoj

Indexed as

GlaucomaSterolsAlkynesAnimalsBenzoxazinesCholesterol 24-HydroxylaseClusterinCyclopropanesMiceAlkynesBenzoxazinesCholesterol 24-HydroxylaseClusterinCyclopropanesefavirenzSterols24-hydroxycholesterolAPOJCholesterolEfavirenzGlaucomaRetina

Identifiers

PMID37392222
PMCPMC10314885
OpenAlexW4382795606

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.