ArticleCNS neuroscience & therapeutics2023
Altered large-scale individual-based morphological brain network in spinocerebellar ataxia type 3.
Article in CNS neuroscience & therapeutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 10 citations in OpenAlex.
- Mapping the Disrupted Connectome in Spinocerebellar Ataxia Type 3: A Network-Based Statistics Study Identifying Novel Therapeutic Targets for Neuromodulation.CNS neuroscience & therapeutics · 2026Article
- Altered individual-level morphological similarity network in children with growth hormone deficiency.Journal of neurodevelopmental disorders · 2024Article
- Disrupted individual-level morphological brain network in spinal muscular atrophy types 2 and 3.CNS neuroscience & therapeutics · 2024Article
- Altered large-scale individual-based morphological brain network in spinocerebellar ataxia type 3.CNS neuroscience & therapeutics · 2023Article
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundAccumulating evidences indicate regional gray matter (GM) morphology atrophy in spinocerebellar ataxia type 3 (SCA3); however, whether large-scale morphological brain networks (MBNs) undergo widespread reorganization in these patients remains unclear.
objectiveTo investigate the topological organization of large-scale individual-based MBNs in SCA3 patients.
methodsThe individual-based MBNs were constructed based on the inter-regional morphological similarity of GM regions. Graph theoretical analysis was taken to assess GM structural connectivity in 76 symptomatic SCA3, 24 pre-symptomatic SCA3, and 54 healthy normal controls (NCs). Topological parameters of the resulting graphs and network-based statistics analysis were compared among symptomatic SCA3, pre-symptomatic SCA3, and NCs groups. The inner association between network properties and clinical variables was further analyzed.
resultsCompared to NCs and pre-symptomatic SCA3 patients, symptomatic SCA3 indicated significantly decreased integration and segregation, a shift to "weaker small-worldness", characterized by decreased C
conclusionSymptomatic SCA3 patients undergo an extensive and significant reorganization in large-scale individual-based MBNs, probably due to disrupted prefrontal cortico-striato-thalamo-cortical loops, limbic-striatum circuitry, and enhanced connectivity in the neostriatum. This study highlights the crucial role of abnormal morphological connectivity alterations beyond the pattern of brain atrophy, which might pave the way for therapeutic development in the future.
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