ArticleMolecular plant2023
The AFB1 auxin receptor controls the cytoplasmic auxin response pathway in Arabidopsis thaliana.
Article in Molecular plant, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29 citing papers in PubMed, 63 citations in OpenAlex.
- Live Imaging of Grass Roots Growth Dynamics Using Microfluidics.Methods in molecular biology (Clifton, N.J.) · 2027Article
- Protein persulfidation in plants: a central regulator of multiple signaling pathways.Plant cell reports · 2026Review
- Metabolism meets transport: a new perspective on auxin homeostasis at subcellular level.Planta · 2026Review
- A telomere-to-telomere gap-free genome of the new cultivar 'Zhongtian No. 5', combined with pan-genome analysis, aids in exploration and genetic enhancement of red clover (Horticulture research · 2026Article
- Thermosensory reconfiguration of the auxin transcriptional pathway to drive root cell growth.Nature communications · 2026Article
- Auxin Biosynthesis, Transport, Signaling, and Its Roles in Plant Leaf Morphogenesis.Plants (Basel, Switzerland) · 2025Review
- Hormonal regulation of root growth under moderately elevated temperatures.Annals of botany · 2025Review
- Aux/IAAs: specificity and redundancy.Plant signaling & behavior · 2025Review
- Mechanisms of auxin action in plant growth and development.Nature reviews. Molecular cell biology · 2025Review
- Cytosolic- and membrane-localized oxidized indole-3-acetic acid formation regulates developmental auxin transients.Plant physiology · 2025Article
- Extracellular pH, cell length and cell differentiation do not firmly correlate across Arabidopsis root tissues.Plant & cell physiology · 2025Article
- Screening and Validation of Reference Genes for Normalization of qRT-PCR in Rice BLB PathogenGenes · 2025Article
- BTB/POZ-MATH proteins regulate Arabidopsis seedling development by promoting auxin-independent degradation of the Aux/IAA protein IAA10.Plant physiology · 2025Article
- Branching angles in the modulation of plant architecture: Molecular mechanisms, dynamic regulation, and evolution.Plant communications · 2025Review
- Historical and mechanistic perspective on ABP1-TMK1-mediated cell surface auxin signaling.NPJ science of plants · 2025Review
- Slow and rapid auxin responses in Arabidopsis.Journal of experimental botany · 2024Article
- Genetically Encoded, Noise-Tolerant, Auxin Biosensors in Yeast.ACS synthetic biology · 2024Article
- Indole-3-propionic acid regulates lateral root development by targeting auxin signaling iniScience · 2024Article
- An auxin research odyssey: 1989-2023.The Plant cell · 2024Review
- The new horizon of plant auxin signaling via cell-surface co-receptors.Cell research · 2024Article
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9 authors at 3 institutions in 2 countries.
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Abstract
The phytohormone auxin triggers root growth inhibition within seconds via a non-transcriptional pathway. Among members of the TIR1/AFB auxin receptor family, AFB1 has a primary role in this rapid response. However, the unique features that confer this specific function have not been identified. Here we show that the N-terminal region of AFB1, including the F-box domain and residues that contribute to auxin binding, is essential and sufficient for its specific role in the rapid response. Substitution of the N-terminal region of AFB1 with that of TIR1 disrupts its distinct cytoplasm-enriched localization and activity in rapid root growth inhibition by auxin. Importantly, the N-terminal region of AFB1 is indispensable for auxin-triggered calcium influx, which is a prerequisite for rapid root growth inhibition. Furthermore, AFB1 negatively regulates lateral root formation and transcription of auxin-induced genes, suggesting that it plays an inhibitory role in canonical auxin signaling. These results suggest that AFB1 may buffer the transcriptional auxin response, whereas it regulates rapid changes in cell growth that contribute to root gravitropism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.