ArticleAmerican journal of Alzheimer's disease and other dementias
Obesity in Late-Life as a Protective Factor Against Dementia and Dementia-Related Mortality.
Article in American journal of Alzheimer's disease and other dementias. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Identifying and Addressing Unmet Needs in Dementia: The Role of Care Access and Psychosocial Support.International journal of geriatric psychiatry · 2025Trial
- Unraveling the causal web of 4 adiposity indices and 92 multi-system outcomes: A body-wide Mendelian randomization study.Medicine · 2026Article
- Social and Cardiovascular Risk Factors as Predictors of the Progression from Mild Cognitive Impairment to Dementia in a Large EHR Database.medRxiv : the preprint server for health sciences · 2026Article
- Population attributable fraction of modifiable risk factors for dementia in the Democratic Republic of Congo: A community-based cross-sectional analysis.medRxiv : the preprint server for health sciences · 2026Article
- Losses to Follow-Up in a Nationally Representative Study of Community-Living Older Americans: Two Approaches to Censoring and Implications for Mortality Outcomes.Journal of the American Geriatrics Society · 2026Article
- Is Work-Related Hearing Loss Associated With Dementia? Evidence From a High-Risk Population.American journal of industrial medicine · 2025Article
- Association Between Anthropometry and Cognitive Impairment in Patients with Type 2 Diabetes: Secondary Analysis from the 'Cognition in Diabetes' Study.TouchREVIEWS in endocrinology · 2025Article
- Visit-to-visit body mass index variability in relation to longitudinal cognitive changes in Chinese adults: a retrospective cohort study.BMC public health · 2025Article
- Weight of time: exploring the link between obesity and aging.Aging clinical and experimental research · 2025Review
- Incomplete Ascertainment of Mortality in a Nationally Representative Longitudinal Study of Community-Living Older Americans.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- The Association Between the Weight-Adjusted Waist Index and Dementia Risk in Older Adults: A Prospective Cohort Study.Healthcare (Basel, Switzerland) · 2025Article
- Predicting dementia in people with Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Body mass index changes and trajectories from midlife to late-life: association with subjective cognitive complaints in a 30-year Women's cohort study.Age and ageing · 2025Article
- Multisystem failure, tipping points, and risk of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Cardiometabolic Multimorbidity and Dementia Onset Among Middle-Aged and Older Adults: Differences by Race/Ethnicity.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Observational
- Associations of body mass index and waist circumference with all cause mortality in the oldest old with cognitive impairment: a prospective cohort study.Frontiers in nutrition · 2025Article
- Body Composition and Alzheimer's Disease: A Holistic Review.International journal of molecular sciences · 2024Review
- Neuro-Adipokine Crosstalk in Alzheimer's Disease.International journal of molecular sciences · 2024Review
- Feeding Modality and Longitudinal Nutritional Status in Severe Dementia: A Matched Cohort Study.American journal of Alzheimer's disease and other dementiasArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectiveWe estimated the conversion from cognitively normal to mild cognitive impairment (MCI) to probable dementia and death for underweight, normal, overweight, and obese older adults, where the timing of examinations is associated with the severity of dementia.
methodsWe analyzed six waves of the National Health and Aging Trends Study (NHATS). Body mass (BMI) was computed from height and weight. Multi-state survival models (MSMs) examined misclassification probability, time-to-event ratios, and cognitive decline.
resultsParticipants (n = 6078) were 77 years old, 62% had overweight and/or obese BMI. After adjusting for the effects of cardiometabolic factors, age, sex, and race, obesity was protective against developing dementia (aHR=.44; 95%CI [.29-.67]) and dementia-related mortality (aHR=.63; 95%CI [.42-.95]). DISCUSSION: We found a negative relationship between obesity and dementia and dementia-related mortality, a finding that has been underreported in the literature. The continuing obesity epidemic might complicate the diagnosis and treatment of dementia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.