ArticleBMC genomics2023
Integrated multi-omics analysis reveals variation in intramuscular fat among muscle locations of Qinchuan cattle.
Article in BMC genomics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 39 citations in OpenAlex.
- Breed-specific meat quality and flavor characteristics of Wannan and Chinese Simmental cattle revealed by whole transcriptome and metabolome analysis.Food chemistry. Molecular sciences · 2026Article
- Fetal programming is associated with candidate lipidomic signatures in skeletal muscle of Nellore beef cattle offspring.Scientific reports · 2026Article
- Applications of omics-based phenotyping technologies in animal genetic breeding.Science China. Life sciences · 2026Review
- Stearoyl-CoA desaturase 5 (SCD5) in lipid remodeling: From molecular control to pathophysiology.Journal of lipid research · 2026Review
- Integrated LC-MS-based lipidomics and transcriptomics reveal lipid heterogeneity and flavour variation in different cuts of muscles from Sadumont lamb.Food chemistry. Molecular sciences · 2026Article
- Dynamic m⁶A methylation during bovine preadipocyte differentiation and functional implication of the m⁶A writer METTL14.BMC genomics · 2026Article
- Effect of supplemental feeding on metabolic profiles and meat quality in yaks: a non-targeted metabolomics approach.Food science of animal resources · 2026Article
- Integrating Transcriptomics and Metabolomics to Elucidate the Molecular Mechanisms Underlying Beef Quality Variations.Foods (Basel, Switzerland) · 2026Article
- Article
- Metabolomic, lipidomic and transcriptomic profiles provide insights into meat quality differences among four pork cuts.BMC genomics · 2025Article
- Integrated multi-omics reveals potential regulatory mechanisms of meat quality.Food chemistry. Molecular sciences · 2025Article
- Review
- MCEE Promotes Intramuscular Fat Deposition in Pigs Through Regulating Mitochondrial Function.Animals : an open access journal from MDPI · 2025Article
- Mechanisms of Variation in Abdominal Adipose Color Among Male Kazakh Horses Through Non-Coding RNA Sequencing.Biology · 2025Article
- Characterization and comparison of flavor compounds in different specialty chicken meat after stewing.Food chemistry: X · 2025Article
- Integrated Transcriptomic Analysis of Liver and Muscle Tissues Reveals Candidate Genes and Pathways Regulating Intramuscular Fat Deposition in Beef Cattle.Animals : an open access journal from MDPI · 2025Article
- Integrated transcriptomics and metabolomics reveal the molecular characteristics and metabolic regulatory mechanisms among different muscles in Minxian black fur sheep.BMC genomics · 2025Article
- Genetic advancements and future directions in ruminant livestock breeding: from reference genomes to multiomics innovations.Science China. Life sciences · 2025Review
- Multi-Omics Analysis Revealed the Molecular Mechanisms Affecting Average Daily Gain in Cattle.International journal of molecular sciences · 2025Article
- Circ_0011446 Regulates Intramuscular Adipocyte Differentiation in Goats via the miR-27a-5p/FAM49B Axis.International journal of molecular sciences · 2025Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIntramuscular fat (IMF) is closely related to the tenderness, marbling, juiciness, and flavor of meat. We used a combined transcriptome and metabolome analysis to investigate the molecular mechanisms underlying phenotypic variation among Qinchuan cattle.
resultsThe IMF content was relatively high in the meat of Qinchuan cattle bulls and differed among muscle locations, namely the high rib (15.86%), ribeye (14%), striploin (10.44%), and tenderloin (8.67%). CCDC80 and the HOX gene cluster may regulate intramuscular adipose tissue deposition. Moreover, erucic acid (EA) was found to be the main metabolite in Qinchuan beef cattle, with a high concentration in IMF. The deposition of IMF could be regulated by the metabolic pathway for unsaturated fatty acids involving EA and the ACOX3, HACD2, and SCD5 genes. In addition, differentially expressed genes and metabolites were enriched in three major KEGG pathways: purine metabolism, pyrimidine metabolism, and the metabolism of glycine, serine, and threonine.
conclusionsWe identified a significant metabolite, EA, with variation in IMF. Its closely related genes, ACOX3, HACD2, and SCD5, co-regulate the metabolism of unsaturated fatty acids, ultimately affecting the accumulation of intramuscular adipose tissue in Qinchuan cattle. Consequently, Qinchuan cattle are an elite cultivar for high-quality beef production and have great potential for breeding.
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