SynthesisBMC pediatrics2023
Comparison of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio for the diagnosis of neonatal sepsis: a systematic review and meta-analysis.
Synthesis in BMC pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between neutrophil to lymphocyte ratio and the mortality of patients with sepsis: an update systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Diagnostic value of platelet-lymphocyte ratio for pediatric sepsis: A systematic review and meta-analysis.Pakistan journal of medical sciences · 2026Article
- Clinical Characteristics and Antimicrobial Resistance ofInfection and drug resistance · 2026Article
- Unveiling the Power of Platelet-to-Lymphocyte Ratio as a Game-Changer in Late-Onset Neonatal Sepsis Diagnosis.Children (Basel, Switzerland) · 2025Article
- Clinical Yield of Acute Inflammatory Markers in the Pediatric Emergency Department.Clinical pediatrics · 2025Article
- Comparison of the accuracy of hematological parameters in the diagnosis of neonatal sepsis: a network meta-analysis.Infection · 2025Article
- Establishing a Predictive Model for the Occurrence of CI-AKI After PCI in Patients With Coronary Heart Disease Based on Serum-Derived Biomarkers.Cardiology research and practice · 2025Article
- Systemic immune-inflammatory complex index as a novel predictor of sepsis prognosis: a retrospective cohort study using MIMIC-IV.Frontiers in medicine · 2025Article
- Assessment of neutrophil to lymphocyte ratio, platelet to lymphocyte ratio and systemic immune-inflammatory index, as diagnostic markers for neonatal sepsis.The Journal of international medical research · 2024Article
- Role of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in diagnosing neonatal sepsis.Narra J · 2024Article
- Predictive Role of NLR, dNLR, PLR, NLPR, and Other Laboratory Markers in Diagnosing SIRS in Premature Newborns.Clinics and practice · 2024Article
- Abnormal neutrophil-to-lymphocyte ratio in children with autism spectrum disorder and history of maternal immune activation.Scientific reports · 2023Article
- The Neutrophil-to-Lymphocyte Ratio (NLR) Can Predict Sepsis's Presence and Severity in Malnourished Infants-A Single Center Experience.Children (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo compare the performance of Neutrophil-to-Lymphocyte Ratio (NLR) with that of Platelet-to-Lymphocyte Ratio (PLR) in diagnosing neonatal sepsis (NS).
methodsPubMed and Embase were searched for relevant studies from the inception of the databases to May, 2022. The pooled sensitivity (SEN), specificity (SPE), and area under the receiver operator characteristic curve (AUC) were measured.
resultsThirteen studies involving 2610 participants were included. The SEN, SPE, and AUC of NLR were 0.76 (95%CI: 0.61-0.87), 0.82 (95%CI: 0.68-0.91), and 0.86 (95%CI: 0.83-0.89), respectively, and those of PLR were 0.82 (95%CI: 0.63-0.92), 0.80 (95%CI: 0.24-0.98), and 0.87 (95%CI: 0.83-0.89), respectively. Significant heterogeneity was observed among the studies. Subgroup analysis and meta-regression showed that types of sepsis (p = 0.01 for SEN), gold standard (p = 0.03 for SPE), and pre-set threshold (p<0.05 for SPE) might be the sources of heterogeneity for NLR, whereas the pre-set threshold (p<0.05 for SPE) might be the source of heterogeneity for PLR.
conclusionsNLR and PLR would be of great accuracy for the diagnosis of NS, and the two indicators have similar diagnostic performance. However, the overall risk of bias was high, and significant heterogeneity was identified among the included studies. The results of this study should be interpreted prudently, and the normal or cut-off values and the type of sepsis should be considered. More prospective studies are needed to further support the clinical application of these findings.
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