Evidence map›Paper›PMID 37391545›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2023

Long-term impact of myocardial inflammation on quantitative myocardial perfusion-a descriptive PET/MR myocarditis study.

Ronny R Buechel, Domenico Ciancone, Adam Bakula, Elia von Felten, Gian-Andrea Schmidt, Dimitri Patriki, Christoph Gräni, Andreas Wahl, Robert Manka, Bettina Heidecker and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. CD45-targeted PET enables the visualization of inflammatory conditions.American journal of nuclear medicine and molecular imaging · 2025
    Article
  2. Recent Progress of Cardiac MRI for Nuclear Medicine Professionals.Nuclear medicine and molecular imaging · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Ronny R BuechelDepartment of Nuclear Medicine, Cardiac Imaging, University and University Hospital Zurich, Ramistrasse 100, NUK A 12, 8091, Zurich, Switzerland. ronny.buechel@usz.ch.
Domenico CianconeDepartment of Nuclear Medicine, Cardiac Imaging, University and University Hospital Zurich, Ramistrasse 100, NUK A 12, 8091, Zurich, Switzerland.
Adam BakulaDepartment of Nuclear Medicine, Cardiac Imaging, University and University Hospital Zurich, Ramistrasse 100, NUK A 12, 8091, Zurich, Switzerland.
Elia von FeltenDepartment of Nuclear Medicine, Cardiac Imaging, University and University Hospital Zurich, Ramistrasse 100, NUK A 12, 8091, Zurich, Switzerland.
Gian-Andrea SchmidtDepartment of Nuclear Medicine, Cardiac Imaging, University and University Hospital Zurich, Ramistrasse 100, NUK A 12, 8091, Zurich, Switzerland.
Dimitri PatrikiDepartment of Nuclear Medicine, Cardiac Imaging, University and University Hospital Zurich, Ramistrasse 100, NUK A 12, 8091, Zurich, Switzerland.
Christoph GräniDepartment of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Andreas WahlDepartment of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Robert MankaDepartment of Cardiology, University and University Hospital of Zurich, Zurich, Switzerland.
Bettina HeideckerDepartment of Cardiology, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin und Humboldt-Universität zu Berlin, Berlin, Germany.
Dominik C BenzDepartment of Nuclear Medicine, Cardiac Imaging, University and University Hospital Zurich, Ramistrasse 100, NUK A 12, 8091, Zurich, Switzerland.
Andreas A GiannopoulosDepartment of Nuclear Medicine, Cardiac Imaging, University and University Hospital Zurich, Ramistrasse 100, NUK A 12, 8091, Zurich, Switzerland.
Aju P PazhenkottilDepartment of Nuclear Medicine, Cardiac Imaging, University and University Hospital Zurich, Ramistrasse 100, NUK A 12, 8091, Zurich, Switzerland.
Philipp A KaufmannDepartment of Nuclear Medicine, Cardiac Imaging, University and University Hospital Zurich, Ramistrasse 100, NUK A 12, 8091, Zurich, Switzerland.
University Hospital of Zurich · CHFreie Universität Berlin · DEUniversity Hospital of Bern · CHUniversity of Bern · CH

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung Project No. 175640
6 · The paper itself

Abstract

purposeWhether myocardial inflammation causes long-term sequelae potentially affecting myocardial blood flow (MBF) is unknown. We aimed to assess the effect of myocardial inflammation on quantitative MBF parameters, as assessed by 13N-ammonia positron emission tomography myocardial perfusion imaging (PET-MPI) late after myocarditis.

methodsFifty patients with a history of myocarditis underwent cardiac magnetic resonance (CMR) imaging at diagnosis and PET/MR imaging at follow-up at least 6 months later. Segmental MBF, myocardial flow reserve (MFR), and 13N-ammonia washout were obtained from PET, and segments with reduced 13N-ammonia retention, resembling scar, were recorded. Based on CMR, segments were classified as remote (n = 469), healed (inflammation at baseline but no late gadolinium enhancement [LGE] at follow-up, n = 118), and scarred (LGE at follow-up, n = 72). Additionally, apparently healed segments but with scar at PET were classified as PET discordant (n = 18).

resultsCompared to remote segments, healed segments showed higher stress MBF (2.71 mL*min

conclusionIn patients with a history of myocarditis, quantitative measurements of myocardial perfusion as obtained from PET-MPI remain altered in areas initially affected by inflammation. CMR = cardiac magnetic resonance; PET = positron emission tomography; LGE = late gadolinium enhancement.

Indexed as

Coronary Artery DiseaseMyocardial Perfusion ImagingMyocarditisAmmoniaCicatrixContrast MediaCoronary CirculationGadoliniumHumansInflammationMagnetic Resonance ImagingNitrogen RadioisotopesPerfusionPositron-Emission TomographyRadiopharmaceuticalsAmmoniaContrast MediaGadoliniumNitrogen-13Nitrogen RadioisotopesRadiopharmaceuticalsCardiac magnetic resonanceInflammationMyocardial blood flowMyocarditisPerfusionPositron emission tomography

Identifiers

PMID37391545
PMCPMC10547808
OpenAlexW4382651779

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.