Evidence map›Paper›PMID 37391431›Full record

ArticleNature communications2023

TRPA1 activation in non-sensory supporting cells contributes to regulation of cochlear sensitivity after acoustic trauma.

A Catalina Vélez-Ortega, Ruben Stepanyan, Stephanie E Edelmann, Sara Torres-Gallego, Channy Park, Desislava A Marinkova, Joshua S Nowacki, Ghanshyam P Sinha, Gregory I Frolenkov

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

  1. Molecular divergence ofZoological research · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Role of TRP Channels in Cancer-Induced Bone Pain.International journal of molecular sciences · 2025
    Review
  6. Review
  7. TRP channels in mammalian hearing loss.Frontiers in molecular neuroscience · 2025
    Review
  8. Transient Receptor Potential (TRP) Channels in Cochlear Function: Looking Beyond Mechanotransduction.Journal of the Association for Research in Otolaryngology : JARO · 2024
    Article
  9. Localization of cadherins in the postnatal cochlear epithelium and their relation to space formation.Developmental dynamics : an official publication of the American Association of Anatomists · 2024
    Article
  10. TRPA1, TRPV1, and Caffeine: Pain and Analgesia.International journal of molecular sciences · 2024
    Review
  11. Optogenetics Reveals Roles for Supporting Cells in Force Transmission to and From Outer Hair Cells in the Mouse Cochlea.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

A Catalina Vélez-OrtegaDepartment of Physiology, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA. catavelezo@uky.edu.ORCID 0000-0001-9157-8390
Ruben StepanyanDepartment of Physiology, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA.
Stephanie E EdelmannDepartment of Physiology, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA.
Sara Torres-GallegoDepartment of Physiology, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA.
Channy ParkDepartment of Head & Neck Surgery, David Geffen School of Medicine, UCLA, Los Angeles, CA, 90095, USA.
Desislava A MarinkovaDepartment of Physiology, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA.
Joshua S NowackiDepartment of Physiology, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA.
Ghanshyam P SinhaDepartment of Physiology, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA.ORCID 0000-0003-3190-2878
Gregory I FrolenkovDepartment of Physiology, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA. Gregory.Frolenkov@uky.edu.ORCID 0000-0002-9810-5024
University of Kentucky · USUniversity of California, Los Angeles · US

Funding

Repair of mechano-electrical transduction in mammalian auditory hair cellsR01DC014658 · NIDCD · UNIVERSITY OF KENTUCKY · PI FROLENKOV, GREGORY I · 2015 to 2019
$2.0M
Regulation of outer hair cell electromotility and noise-induced hearing lossR01DC009434 · NIDCD · UNIVERSITY OF KENTUCKY · PI FROLENKOV, GREGORY I · 2009 to 2013
$1.3M
Olympus BX-DSU Live-Cell Disk Scanning Imaging / Electrophysiology SystemS10RR027400 · NCRR · UNIVERSITY OF KENTUCKY · PI TAYLOR, BRADLEY K. · 2010 to 2010
$297k
NCRR NIH HHS S10 RR027400NIDCD NIH HHS R01 DC009434NIDCD NIH HHS R01 DC014658
6 · The paper itself

Abstract

TRPA1 channels are expressed in nociceptive neurons, where they detect noxious stimuli, and in the mammalian cochlea, where their function is unknown. Here we show that TRPA1 activation in the supporting non-sensory Hensen's cells of the mouse cochlea causes prolonged Ca

Indexed as

Hearing Loss, Noise-InducedTRPA1 Cation ChannelAnimalsCochleaEpithelial CellsEvoked Potentials, Auditory, Brain StemLabyrinth Supporting CellsMiceTRPA1 Cation ChannelTrpa1 protein, mouse

Identifiers

PMID37391431
PMCPMC10313773
OpenAlexW4382777023

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.