Evidence map›Paper›PMID 37391098›Full record

ArticleFree radical biology & medicine2023

Covalent adduction of serotonin-derived quinones to the SARS-CoV-2 main protease expressed in a cultured cell.

Yoji Kato, Asahi Sakanishi, Kaoru Matsuda, Mai Hattori, Ichiro Kaneko, Miyu Nishikawa, Shinichi Ikushiro

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Free radical biology & medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Yoji KatoSchool of Human Science and Environment, University of Hyogo, Himeji, Hyogo, 670-0092, Japan; Research Institute for Food and Nutritional Sciences, University of Hyogo, Himeji, Hyogo, 670-0092, Japan. Electronic address: yojikato@shse.u-hyogo.ac.jp.
Asahi SakanishiSchool of Human Science and Environment, University of Hyogo, Himeji, Hyogo, 670-0092, Japan.
Kaoru MatsudaSchool of Human Science and Environment, University of Hyogo, Himeji, Hyogo, 670-0092, Japan.
Mai HattoriSchool of Human Science and Environment, University of Hyogo, Himeji, Hyogo, 670-0092, Japan.
Ichiro KanekoSchool of Human Science and Environment, University of Hyogo, Himeji, Hyogo, 670-0092, Japan; Research Institute for Food and Nutritional Sciences, University of Hyogo, Himeji, Hyogo, 670-0092, Japan.
Miyu NishikawaDepartment of Biotechnology, Faculty of Engineering, Toyama Prefectural University, Imizu, Toyama, 939-0398, Japan.
Shinichi IkushiroDepartment of Biotechnology, Faculty of Engineering, Toyama Prefectural University, Imizu, Toyama, 939-0398, Japan.
University of Hyogo · JPToyama Prefectural University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The SARS-CoV-2 main protease is an essential molecule for viral replication and is often targeted by medications to treat the infection. In this study, we investigated the possible inhibitory action of endogenous quinones on the enzyme. Recombinant SARS-CoV-2 main protease was exposed to tryptamine-4,5-dione (TD) or quinone from 5-hydroxyindoleacetic acid (Q5HIAA). As a result, the protease activity was considerably decreased in a dose-dependent manner. The IC

Indexed as

COVID-19QuinonesBenzoquinonesCells, CulturedCoronavirus 3C ProteasesHumansProtease InhibitorsSARS-CoV-2SerotoninTryptamines3C-like proteinase, SARS-CoV-2BenzoquinonesCoronavirus 3C ProteasesProtease InhibitorsquinoneQuinonesSerotonintryptamineTryptaminesCovalent inhibitorIntracellular reactionSARS-CoV-2 main proteaseSerotonin quinone

Identifiers

PMID37391098
PMCPMC10300202
OpenAlexW4382404914

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.