Evidence map›Paper›PMID 37390823›Full record

ArticleStem cell reports2023

Cell-autonomous and non-cell-autonomous roles of NKCC1 in regulating neural stem cell quiescence in the hippocampal dentate gyrus.

Feng Zhang, Kijun Yoon, Nam-Shik Kim, Guo-Li Ming, Hongjun Song

Open access · goldAbstract read
In one paragraph

Article in Stem cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. SETDB1 ensures the continuity of embryonic to adult neural stem cells through metabolic alterations in the dentate gyrus.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. mCell stem cell · 2025
    Article
  6. mCell stem cell · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Feng ZhangDepartment of Neuroscience and Mahoney Institute for Neurosciences, Philadelphia, PA 19104, USA.
Kijun YoonDepartment of Neuroscience and Mahoney Institute for Neurosciences, Philadelphia, PA 19104, USA.
Nam-Shik KimDepartment of Neuroscience and Mahoney Institute for Neurosciences, Philadelphia, PA 19104, USA.
Guo-Li MingDepartment of Neuroscience and Mahoney Institute for Neurosciences, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, Philadelphia, PA 19104, USA; Department of Psychiatry, Philadelphia, PA 19104, USA; Institute for Regenerative Medicine, Philadelphia, PA 19104, USA.
Hongjun SongDepartment of Neuroscience and Mahoney Institute for Neurosciences, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, Philadelphia, PA 19104, USA; Institute for Regenerative Medicine, Philadelphia, PA 19104, USA; The Epigenetics Institute, Perelman School of Medicine, Philadelphia, PA 19104, USA. Electronic address: shongjun@pennmedicine.upenn.edu.
California Institute for Regenerative Medicine · US

Funding

Continuous Neurogenesis in the Mammalian HippocampusR35NS116843 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI HONGJUN SONG · 2020 to 2026
$6.9M
Functional roles of genetic risk factors for brain disorders in neurogenesis and neurodevelopmentR35NS097370 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI MING, GUO-LI · 2017 to 2024
$6.7M
NINDS NIH HHS R35 NS097370NINDS NIH HHS R35 NS116843
6 · The paper itself

Abstract

Quiescence is a hallmark of adult neural stem cells (NSCs) in the mammalian brain, and establishment and maintenance of quiescence is essential for life-long continuous neurogenesis. How NSCs in the dentate gyrus (DG) of the hippocampus acquire their quiescence during early postnatal stages and continuously maintain quiescence in adulthood is poorly understood. Here, we show that Hopx-CreER

Indexed as

HippocampusNeural Stem CellsAnimalsCell DivisionDentate GyrusMammalsMiceNeurogenesisadult neurogenesisbumetanidedentate gyrusGABAhippocampusinterneuronsneural stem cellsquiescence

Identifiers

PMID37390823
PMCPMC10362507
OpenAlexW4382722012

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.