ArticleNeuron2023
Cortical somatostatin interneuron subtypes form cell-type-specific circuits.
Abstract read
In one paragraph
Article in Neuron, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers.
0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
88 citing papers in PubMed.
- Early adversity promotes adolescent avoidance behavior by enhancing prefrontal-amygdala communication through CRHbioRxiv : the preprint server for biology · 2026Article
- SST interneurons facilitate dendritic calcium signaling via tonic activation of α5-GABA receptors.Neuron · 2026Article
- Article
- Layer 6 corticothalamic neurons show diverse and dynamic responses that support a role in cortical gain control in noisy environments.bioRxiv : the preprint server for biology · 2026Article
- Context-dependent effects of SOM neurons to enhance the responses of corticocollicular neurons to repetitive sounds.iScience · 2026Article
- Mechanism-guided identification of antidepressant G protein-coupled receptor drug targets.Cell · 2026Article
- Probing molecular diversity and ultrastructure of brain cells with fluorescent aptamers.Nature communications · 2026Article
- Psilocybin reshapes cortical inhibition through selective interneuron recruitment.bioRxiv : the preprint server for biology · 2026Article
- A multimodal approach for visualizing and identifying electrophysiological cell types in vivo.Nature communications · 2026Article
- Circuit Organization of the Forelimb-Related M2-to-M1 Corticocortical Pathway in the Mouse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Article
- Morphoelectric Diversity and Specialization of Neuronal Cell Types in the Primate Striatum.bioRxiv : the preprint server for biology · 2026Article
- Reducing methylation of histone 3.3 lysine 4 in the medial ganglionic eminence and hypothalamus recapitulates neurodevelopmental disorder phenotypes.Nature communications · 2026Article
- Uncovering the signatures of aging and senescence in the human dorsolateral prefrontal cortex.Cell genomics · 2026Article
- Cortical Somatostatin Innervation Follows a Unique Experience-Independent Developmental Trajectory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Circuit organization of the forelimb-related M2-to-M1 corticocortical pathway in the mouse.bioRxiv : the preprint server for biology · 2026Article
- Dysfunction of GABAergic interneurons underlies altered neural network oscillations associated with epileptiform activity in PPT1-deficient mice.Translational psychiatry · 2026Article
- Sexually dimorphic plasticity of PV inhibition in sensory neocortex during learning.Scientific reports · 2026Article
- Chronic nicotine reverses age-related decline of interneuron markers in mouse auditory cortex.Frontiers in aging neuroscience · 2026Article
- Inhibitory circuit motifs of cortical somatosensory layer 5 SST interneurons are uniform within layers but specific across layers.The Journal of physiology · 2026Article
28 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors.
Sherry Jingjing WuHarvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Elaine SevierHarvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Deepanjali DwivediHarvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Giuseppe-Antonio SaldiStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Ariel HairstonHarvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Sabrina YuDepartment of Health Sciences, Bouvé College of Health Sciences, Northeastern University, Boston, MA, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Lydia AbbottDepartment of Biology, College of Science, Northeastern University, Boston, MA, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Da Hae ChoiDepartment of Behavioral Neuroscience, College of Science, Northeastern University, Boston, MA 02115, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Mia ShererHarvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Yanjie QiuHarvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Ashwini ShindeDepartment of Behavioral Neuroscience, College of Science, Northeastern University, Boston, MA 02115, USA; Harvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA.
Mackenzie LenahanDepartment of Biology, College of Science, Northeastern University, Boston, MA, USA; Harvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA.
Daniella RizzoDepartment of Biology, Brandeis University, Waltham, MA, USA; Harvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA.
Qing XuCenter for Genomics & Systems Biology, New York University Abu Dhabi, Abu Dhabi, UAE.
Irving BarreraStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Vipin KumarStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Giovanni MarreroStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Alvar PrönnekeNeuroscience Institute, New York University School of Medicine, New York, NY, USA.
Shuhan HuangHarvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Klas KullanderDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
David A StaffordDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94708, USA.
Evan MacoskoStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Fei ChenStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Bernardo RudyNeuroscience Institute, New York University School of Medicine, New York, NY, USA.
Gord FishellHarvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: gordon_fishell@hms.harvard.edu.
Funding
Generation of novel cell type specific mouse genetic toolsU19MH114830 · NIMH · ALLEN INSTITUTE · PI ZENG, HONGKUI · 2017 to 2021
$64.7MThe role of genetic and activity dependent cues in the generation of 5HT3aR interneuron diversityP01NS074972 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FROEMKE, ROBERT CROOKS · 2012 to 2023
$15.5MRegional and Genetic Diversity of Cortical InterneuronsR01MH071679 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FISHELL, GORDON J · 2005 to 2020
$8.5MDevelopment and validation of AAV vectors to manipulate specific neuronal subtypes and circuits involved in epilepsy and psychiatric disorders across mammalian species.UG3MH120096 · NIMH · BROAD INSTITUTE, INC. · PI DEVERMAN, BENJAMIN E, FISHELL, GORDON J · 2019 to 2021
$6.7MThe Development and Integration of Early Born SST-Expressing Interneurons in the CortexR01NS081297 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GORDON J FISHELL · 2012 to 2026
$6.6MSuper-Resolution ImagingP30NS072030 · NINDS · HARVARD MEDICAL SCHOOL · PI REGEHR, WADE G · 2011 to 2020
$5.8MThe molecular and cellular basis of cortical interneuron divergenceR37MH071679 · NIMH · HARVARD MEDICAL SCHOOL · PI GORDON J FISHELL · 2022 to 2026
$4.1MSpatiotemporal control of dendritic inhibition by a family of diverse somatostatin-expressing interneuronsR01NS110079 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI RUDY, BERNARDO · 2018 to 2022
$3.0MInhibitory and Disinhibitory VIP Interneuron-Mediated Circuits in NeocortexR01NS133751 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Bernardo Rudy · 2023 to 2026
$2.6MLayer 4 circuits and sensory processingR01NS107257 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI RUDY, BERNARDO · 2018 to 2022
$2.1MCortical interneuron subtypes adapt to signals from local pyramidal cellsF32MH125464 · NIMH · HARVARD MEDICAL SCHOOL · PI WU, JINGJING · 2021 to 2023
$224kBDNF shapes the functional maturation of cortical interneuronsF31NS110120 · NINDS · HARVARD MEDICAL SCHOOL · PI FISHER, ELAINE · 2019 to 2021
$93kNIMH NIH HHS F32 MH125464NIMH NIH HHS R01 MH071679NIMH NIH HHS R37 MH071679NIMH NIH HHS U19 MH114830NIMH NIH HHS UG3 MH120096NINDS NIH HHS F31 NS110120NINDS NIH HHS P01 NS074972NINDS NIH HHS P30 NS072030NINDS NIH HHS R01 NS081297NINDS NIH HHS R01 NS107257NINDS NIH HHS R01 NS110079NINDS NIH HHS R01 NS133751
Abstract
The cardinal classes are a useful simplification of cortical interneuron diversity, but such broad subgroupings gloss over the molecular, morphological, and circuit specificity of interneuron subtypes, most notably among the somatostatin interneuron class. Although there is evidence that this diversity is functionally relevant, the circuit implications of this diversity are unknown. To address this knowledge gap, we designed a series of genetic strategies to target the breadth of somatostatin interneuron subtypes and found that each subtype possesses a unique laminar organization and stereotyped axonal projection pattern. Using these strategies, we examined the afferent and efferent connectivity of three subtypes (two Martinotti and one non-Martinotti) and demonstrated that they possess selective connectivity with intratelecephalic or pyramidal tract neurons. Even when two subtypes targeted the same pyramidal cell type, their synaptic targeting proved selective for particular dendritic compartments. We thus provide evidence that subtypes of somatostatin interneurons form cell-type-specific cortical circuits.
Indexed as
InterneuronsNeuronsAxonsParvalbuminsPyramidal CellsSomatostatinParvalbuminsSomatostatincortexinterneuronsintratelencephaliclaminar specificitymonosynaptic rabies tracingoptogeneticspyramidal neuronspyramidal tractreciprocal connectivitysomatostatinspatial transcriptomicssubtypes
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.