ArticleScience advances2023
A localized hydrogel-mediated chemotherapy causes immunogenic cell death via activation of ceramide-mediated unfolded protein response.
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Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18citing papers in PubMed
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18 citing papers in PubMed, 39 citations in OpenAlex.
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- A Biologically Inert Tamoxifen-derived Long-lasting Hydrogel-mediated Immunochemotherapy Can Mitigate Tumour Progression and Activate T Cell Immunity.Chemistry of materials : a publication of the American Chemical Society · 2025Article
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- Dynamic Hydrogels in Breast Tumor Models.Gels (Basel, Switzerland) · 2025Review
- The mTORC2 subunit RICTOR drives breast cancer progression by promoting ganglioside biosynthesis through transcriptional and epigenetic mechanisms.PLoS biology · 2025Article
- Endoplasmic Reticulum Stress: Triggers Microenvironmental Regulation and Drives Tumor Evolution.Cancer medicine · 2025Review
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- Enhancing localized chemotherapy with anti-angiogenesis and nanomedicine synergy for improved tumor penetration in well-vascularized tumors.NPJ systems biology and applications · 2024Article
- Comprehensive review of drug-mediated ICD inhibition of breast cancer: mechanism, status, and prospects.Clinical and experimental medicine · 2024Review
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Corrections and comments
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Authors and funding
23 authors at 4 institutions in 1 country.
Animesh KarLaboratory of Nanotechnology and Chemical Biology, Regional Centre for Biotechnology, NCR Biotech Science Cluster, 3rd Milestone, Faridabad-Gurgaon Expressway, Faridabad, 121001, Haryana, India.ORCID 0000-0003-4078-5677
Dolly JainLaboratory of Nanotechnology and Chemical Biology, Regional Centre for Biotechnology, NCR Biotech Science Cluster, 3 Milestone, Faridabad-Gurgaon Expressway, Faridabad, 121001, Haryana, India.ORCID 0000-0002-7689-5352
Sandeep KumarLaboratory of Nanotechnology and Chemical Biology, Regional Centre for Biotechnology, NCR Biotech Science Cluster, 3 Milestone, Faridabad-Gurgaon Expressway, Faridabad, 121001, Haryana, India.ORCID 0000-0002-1764-7519
Kajal RajputAmity Institute of Integrative Sciences and Health, Amity University Haryana, Panchgaon, Manesar, Gurgaon, 122413, Haryana, India.ORCID 0000-0001-8955-4998
Sanjay PalLaboratory of Nanotechnology and Chemical Biology, Regional Centre for Biotechnology, NCR Biotech Science Cluster, 3 Milestone, Faridabad-Gurgaon Expressway, Faridabad, 121001, Haryana, India.ORCID 0000-0003-3959-6844
Kajal RanaLaboratory of Nanotechnology and Chemical Biology, Regional Centre for Biotechnology, NCR Biotech Science Cluster, 3 Milestone, Faridabad-Gurgaon Expressway, Faridabad, 121001, Haryana, India.ORCID 0000-0002-7487-1648
Raunak KarNational Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, 110067, India.ORCID 0000-0003-1971-5682
Somesh K JhaLaboratory of Nanotechnology and Chemical Biology, Regional Centre for Biotechnology, NCR Biotech Science Cluster, 3 Milestone, Faridabad-Gurgaon Expressway, Faridabad, 121001, Haryana, India.ORCID 0000-0003-2303-0862
Nihal MedatwalAmity Institute of Integrative Sciences and Health, Amity University Haryana, Panchgaon, Manesar, Gurgaon, 122413, Haryana, India.ORCID 0000-0002-3273-9315
Prabhu Srinivas YavvariDepartment of Chemistry, Indian Institute of Science Education and Research, Bhopal, 462066, Madhya Pradesh, India.ORCID 0000-0002-8792-9001
Nishant PandeyLaboratory of Nanotechnology and Chemical Biology, Regional Centre for Biotechnology, NCR Biotech Science Cluster, 3 Milestone, Faridabad-Gurgaon Expressway, Faridabad, 121001, Haryana, India.ORCID 0000-0001-5632-6825
Devashish MehtaAmity Institute of Integrative Sciences and Health, Amity University Haryana, Panchgaon, Manesar, Gurgaon, 122413, Haryana, India.ORCID 0000-0001-9840-0181
Harsh SharmaAmity Institute of Integrative Sciences and Health, Amity University Haryana, Panchgaon, Manesar, Gurgaon, 122413, Haryana, India.ORCID 0000-0002-9862-6794
Debanjan BhattacharyaNational Institute of Pathology, Safdarjung Hospital Campus, Ansari Nagar West, New Delhi, 110029, India.ORCID 0009-0006-3623-3182
Manas K PradhanDepartment of Chemistry, Indian Institute of Science Education and Research, Bhopal, 462066, Madhya Pradesh, India.ORCID 0000-0001-5546-9189
Ravi Datta SharmaAmity Institute of Integrative Sciences and Health, Amity University Haryana, Panchgaon, Manesar, Gurgaon, 122413, Haryana, India.ORCID 0000-0002-1723-3113
Aasheesh SrivastavaDepartment of Chemistry, Indian Institute of Science Education and Research, Bhopal, 462066, Madhya Pradesh, India.ORCID 0000-0002-7346-8072
Usha AgrawalNational Institute of Pathology, Safdarjung Hospital Campus, Ansari Nagar West, New Delhi, 110029, India.ORCID 0000-0001-7539-4102
Arnab MukhopadhyayNational Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, 110067, India.ORCID 0000-0002-5266-7849
Sagar SenguptaNational Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, 110067, India.ORCID 0000-0002-6365-1770
Veena S PatilNational Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, 110067, India.
Avinash BajajLaboratory of Nanotechnology and Chemical Biology, Regional Centre for Biotechnology, NCR Biotech Science Cluster, 3 Milestone, Faridabad-Gurgaon Expressway, Faridabad, 121001, Haryana, India.ORCID 0000-0002-1333-9316
Ujjaini DasguptaAmity Institute of Integrative Sciences and Health, Amity University Haryana, Panchgaon, Manesar, Gurgaon, 122413, Haryana, India.ORCID 0000-0002-2281-078X
Regional Centre for Biotechnology · INNational Institute of Immunology · INIndian Institute of Science Education and Research, Bhopal · INSafdarjang Hospital · IN
Funding
No grant is acknowledged in the PubMed record.
Abstract
Treatment of triple-negative breast cancer (TNBC) is challenging because of its "COLD" tumor immunosuppressive microenvironment (TIME). Here, we present a hydrogel-mediated localized delivery of a combination of docetaxel (DTX) and carboplatin (CPT) (called DTX-CPT-Gel therapy) that ensured enhanced anticancer effect and tumor regression on multiple murine syngeneic and xenograft tumor models. DTX-CPT-Gel therapy modulated the TIME by an increase of antitumorigenic M1 macrophages, attenuation of myeloid-derived suppressor cells, and increase of granzyme B
Indexed as
HydrogelsTriple Negative Breast NeoplasmsAnimalsCD8-Positive T-LymphocytesCeramidesDisease Models, AnimalHumansImmunogenic Cell DeathImmunosuppressive AgentsMiceTumor MicroenvironmentUnfolded Protein ResponseCeramidesHydrogelsImmunosuppressive Agents
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.