Evidence map›Paper›PMID 37389678›Full record

ArticleEuropean journal of ageing2023

Validation of the test for finding word retrieval deficits (WoFi) in detecting Alzheimer's disease in a naturalistic clinical setting.

Eleni-Zacharoula Georgiou, Maria Skondra, Marina Charalampopoulou, Panagiotis Felemegkas, Asimina Pachi, Georgia Stafylidou, Dimitrios Papazachariou, Robert Perneczky, Vasileios Thomopoulos, Antonios Politis and 3 more

Abstract read
In one paragraph

Article in European journal of ageing, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Eleni-Zacharoula GeorgiouMental Health Services, Patras University General Hospital, Department of Medicine, School of Health Sciences, University of Patras, Patras, Greece.
Maria SkondraMental Health Services, Patras University General Hospital, Department of Medicine, School of Health Sciences, University of Patras, Patras, Greece.
Marina CharalampopoulouMental Health Services, Patras University General Hospital, Department of Medicine, School of Health Sciences, University of Patras, Patras, Greece.
Panagiotis FelemegkasMental Health Services, Patras University General Hospital, Department of Medicine, School of Health Sciences, University of Patras, Patras, Greece.
Asimina PachiMental Health Services, Patras University General Hospital, Department of Medicine, School of Health Sciences, University of Patras, Patras, Greece.
Georgia StafylidouDepartment of Speech and Language Therapy, School of Health Rehabilitation Sciences, University of Patras, Patras, Greece.
Dimitrios PapazachariouDepartment of Philology, School of Humanities and Social Sciences, University of Patras, Patras, Greece.
Robert PerneczkyDivision of Mental Health in Older Adults and Alzheimer Therapy and Research Center, Department of Psychiatry and Psychotherapy, University Hospital, Ludwig-Maximilians-Universität Munich, Munich, Germany.
Vasileios ThomopoulosLarge-Scale Machine Learning and Cloud Data Engineering Laboratory (ML@Cloud-Lab), Department of Computer Engineering and Informatics, School of Engineering, University of Patras, Patras, Greece.
Antonios PolitisFirst Department of Psychiatry, Eginition Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Iracema LeroiGlobal Brain Health Institute, Medical School, Trinity College Dublin, The University of Dublin, Dublin, Republic of Ireland.
Polychronis EconomouDepartment of Civil Engineering (Statistics), School of Engineering, University of Patras, Patras, Greece.
Panagiotis AlexopoulosMental Health Services, Patras University General Hospital, Department of Medicine, School of Health Sciences, University of Patras, Patras, Greece. panos.alexopoulos@upatras.gr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDetecting impaired naming capacity contributes to the detection of mild (MildND) and major (MajorND) neurocognitive disorder due to Alzheimer's disease (AD). The Test for Finding Word retrieval deficits (WoFi) is a new, 50-item, auditory stimuli-based instrument.

objectiveThe study aimed to adapt WoFi to the Greek language, to develop a short version of WoFi (WoFi-brief), to compare the item frequency and the utility of both instruments with the naming subtest of the widely used Addenbrooke's cognitive examination III (ACEIIINaming) in detecting MildND and MajorND due to AD.

methodsThis cross-sectional, validation study included 99 individuals without neurocognitive disorder, as well as 114 and 49 patients with MildND and MajorND due to AD, respectively. The analyses included categorical principal components analysis using Cramer's V, assessment of the frequency of test items based on corpora of television subtitles, comparison analyses, Kernel Fisher discriminant analysis models, proportional odds logistic regression (POLR) models and stratified repeated random subsampling used to recursive partitioning to training and validation set (70/30 ratio).

resultsWoFi and WoFi-brief, which consists of 16 items, have comparable item frequency and utility and outperform ACEIIINaming. According to the results of the discriminant analysis, the misclassification error was 30.9%, 33.6% and 42.4% for WoFi, WoFi-brief and ACEIIINaming, respectively. In the validation regression model including WoFi the mean misclassification error was 33%, while in those including WoFi-brief and ACEIIINaming it was 31% and 34%, respectively.

conclusionsWoFi and WoFi-brief are more effective in detecting MildND and MajorND due to AD than ACEIIINaming.

Indexed as

Auditory stimuli-based naming testDysnomiaMild and major neurocognitive disorder

Identifiers

PMID37389678
PMCPMC10313575

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.