Evidence map›Paper›PMID 37389617›Full record

ArticleBrain structure & function2023

Kisspeptin neuron projections to oxytocin neurons are not necessary for parturition in the mouse.

Shalini S Kumar, Gregory T Bouwer, Meliame K Jackson, Michael R Perkinson, Fiona J McDonald, Colin H Brown, Rachael A Augustine

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain structure & function, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Shalini S KumarBrain Health Research Centre, University of Otago, Dunedin, New Zealand.
Gregory T BouwerBrain Health Research Centre, University of Otago, Dunedin, New Zealand.
Meliame K JacksonBrain Health Research Centre, University of Otago, Dunedin, New Zealand.
Michael R PerkinsonBrain Health Research Centre, University of Otago, Dunedin, New Zealand.
Fiona J McDonaldDepartment of Physiology, School of Biomedical Sciences, University of Otago, PO Box 56, Dunedin, 9054, New Zealand.
Colin H BrownBrain Health Research Centre, University of Otago, Dunedin, New Zealand.
Rachael A AugustineBrain Health Research Centre, University of Otago, Dunedin, New Zealand. rachael.augustine@otago.ac.nz.ORCID http://orcid.org/0000-0002-6201-1026
Brain Research New Zealand · NZUniversity of Otago · NZ

Funding

New Zealand Health Research Council 14-568
6 · The paper itself

Abstract

Oxytocin is synthesized by hypothalamic supraoptic nucleus (SON) and paraventricular nucleus (PVN) neurons and is released from the posterior pituitary gland to trigger uterine contractions during parturition. In rats, oxytocin neuron innervation by periventricular nucleus (PeN) kisspeptin neurons increases over pregnancy and intra-SON kisspeptin administration excites oxytocin neurons only in late pregnancy. To test the hypothesis that kisspeptin neurons excite oxytocin neurons to trigger uterine contractions during birth in C57/B6J mice, double-label immunohistochemistry for kisspeptin and oxytocin first confirmed that kisspeptin neurons project to the SON and PVN. Furthermore, kisspeptin fibers expressed synaptophysin and formed close appositions with oxytocin neurons in the mouse SON and PVN before and during pregnancy. Stereotaxic viral delivery of caspase-3 into the AVPV/PeN of Kiss-Cre mice before mating reduced kisspeptin expression in the AVPV, PeN, SON and PVN by > 90% but did not affect the duration of pregnancy or the timing of delivery of each pup during parturition. Therefore, it appears that AVPV/PeN kisspeptin neuron projections to oxytocin neurons are not necessary for parturition in the mouse.

Indexed as

KisspeptinsOxytocinAnimalsFemaleMiceNeuronsParaventricular Hypothalamic NucleusParturitionPregnancyRatsKisspeptinsOxytocinKisspeptinOxytocinParaventricular nucleusParturitionPeriventricular nucleusSupraoptic nucleus

Identifiers

PMID37389617
PMCPMC10335956
OpenAlexW4382632214

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.