ReviewJournal of the American College of Cardiology2023
Impact of Geroscience on Therapeutic Strategies for Older Adults With Cardiovascular Disease: JACC Scientific Statement.
Review in Journal of the American College of Cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 35 citations in OpenAlex.
- Multidisciplinary intervention in frail elderly patients with cardiovascular diseases: a multicentre, single-blinded, randomised controlled trial.Nature communications · 2026Trial
- Cardiovascular health, as per life's essential 8, and unhealthy aging trajectories.GeroScience · 2026Article
- Frailty in Cardiorenal Care: A Geriatric Perspective on the 2026 European Society of Cardiology Guidelines.Cureus · 2026Article
- Balance and Mobility Impairment in Older Adults with Cardiovascular Disease Before and After Rehabilitation: A Narrative Review.Journal of clinical medicine · 2026Review
- Cross-species functional transcriptomic analysis distinguishes conserved aging-niche remodeling from inflammatory fibroblast heterogeneity in cardiac aging and heart failure.Functional & integrative genomics · 2026Article
- Impact of resistance training for lowering blood pressure in older adults.American journal of preventive cardiology · 2026Article
- Statin therapy optimization in older adults: interim results of a randomized controlled trial of pharmacist-led pharmaceutical care.GeroScience · 2026Article
- Associations of psychosocial factors with cardiovascular health in aging: insights from the Inlife-Aging Project.GeroScience · 2026Article
- Beyond disease treatment and prevention: From geroscience and molecular hallmarks to gerotherapeutics and precision geromedicine.Journal of the Chinese Medical Association : JCMA · 2026Review
- Assessing health in aging male and female mice: does cardiac function dictate frailty or physical resilience?The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Association of leukocyte mitochondrial DNA copy number and inflammation with mortality among older adults.Communications medicine · 2026Article
- Heterogeneity in Treatment Outcomes After a Multicomponent Weight Loss Intervention in Older Adults with Obesity.Current developments in nutrition · 2026Article
- The Janus face of L-arginine supplementation in cardiovascular health and aging exploration of underlying mechanisms.Frontiers in aging · 2026Review
- Development and external validation of an interpretable machine learning model for obesity-depression comorbidity in Korean and US adults.International journal of public health · 2026Article
- A Simplified Frailty Measure Improves Risk Stratification in Patients Undergoing Percutaneous Mitral Valve Repair.Journal of cachexia, sarcopenia and muscle · 2025Article
- Cardiomyopathy in Older Adults.Current cardiology reports · 2025Review
- Challenges in the prevention, treatment and management of cardiovascular disease among older adults.The Lancet regional health. Europe · 2025Review
- Benefits of Cardiac Rehabilitation: Mechanisms to Restore Function and Clinical Impact.Circulation research · 2025Review
- Healthy ageing in older adults with cardiovascular disease.European heart journal · 2025Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 11 institutions in 1 country.
Funding
Abstract
Geroscience posits that cardiovascular disease (CVD) and other chronic diseases result from progressive erosion of the effectiveness of homeostatic mechanisms that oppose age-related accumulation of molecular damage. This hypothetical common root to chronic diseases explains why patients with CVD are often affected by multimorbidity and frailty and why older age negatively affects CVD prognosis and treatment response. Gerotherapeutics enhance resilience mechanisms that counter age-related molecular damage to prevent chronic diseases, frailty, and disability, thereby extending healthspan. Here, we describe the main resilience mechanisms of mammalian aging, with a focus on how they can affect CVD pathophysiology. We next present novel gerotherapeutic approaches, some of which are already used in management of CVD, and explore their potential to transform care and management of CVD. The geroscience paradigm is gaining traction broadly in medical specialties, with potential to mitigate premature aging, reduce health care disparities, and improve population healthspan.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.