ArticleRadiology. Imaging cancer2023
PET/MRI and Bioluminescent Imaging Identify Hypoxia as a Cause of Programmed Cell Death Ligand 1 Image Heterogeneity.
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Article in Radiology. Imaging cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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5citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 17% of its field
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.
- Pooled it
- Neovascular pruning by IDO1 inhibitors can potentiate immunogenic cytotoxicity of ischemia-targeted agents to synergistically enhance anti-PD-1 responsiveness.Journal for immunotherapy of cancer · 2025Article
- Prostate fibroblasts and prostate cancer associated fibroblasts exhibit different metabolic, matrix degradation and PD-L1 expression responses to hypoxia.Frontiers in molecular biosciences · 2024Article
- Hyperoxic BOLD-MRI-Based Characterization of Breast Cancer Molecular Subtypes Is Independent of the Supplied Amount of Oxygen: A Preclinical Study.Diagnostics (Basel, Switzerland) · 2023Article
- Interrogating the Tumor Microenvironment and Molecular Targets of Immunotherapy: A New Opportunity for Multimodality Imaging.Radiology. Imaging cancer · 2023Article
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Authors and funding
13 authors at 3 institutions in 2 countries.
Katie M Parkins *From the Russell H. Morgan Department of Radiology and Radiological Science (K.M.P., B.K., D.J., S.M.K., M.S., A.M., Y.M., M.F.P., M.T.M., S.N., Z.M.B.), Sidney Kimmel Comprehensive Cancer Center (M.F.P., S.N., Z.M.B.), and Department of Radiation Oncology and Molecular Radiation Sciences (Z.M.B.), The Johns Hopkins University School of Medicine, 720 Rutland Ave, Rm 208C Traylor Building, Baltimore, MD 21205; The F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Md (M.T.M.); and Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tuebingen, Tuebingen, Germany (P.K., B.J.P.).
Balaji Krishnamachary *From the Russell H. Morgan Department of Radiology and Radiological Science (K.M.P., B.K., D.J., S.M.K., M.S., A.M., Y.M., M.F.P., M.T.M., S.N., Z.M.B.), Sidney Kimmel Comprehensive Cancer Center (M.F.P., S.N., Z.M.B.), and Department of Radiation Oncology and Molecular Radiation Sciences (Z.M.B.), The Johns Hopkins University School of Medicine, 720 Rutland Ave, Rm 208C Traylor Building, Baltimore, MD 21205; The F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Md (M.T.M.); and Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tuebingen, Tuebingen, Germany (P.K., B.J.P.).ORCID 0000-0001-6137-5832
Desmond JacobFrom the Russell H. Morgan Department of Radiology and Radiological Science (K.M.P., B.K., D.J., S.M.K., M.S., A.M., Y.M., M.F.P., M.T.M., S.N., Z.M.B.), Sidney Kimmel Comprehensive Cancer Center (M.F.P., S.N., Z.M.B.), and Department of Radiation Oncology and Molecular Radiation Sciences (Z.M.B.), The Johns Hopkins University School of Medicine, 720 Rutland Ave, Rm 208C Traylor Building, Baltimore, MD 21205; The F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Md (M.T.M.); and Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tuebingen, Tuebingen, Germany (P.K., B.J.P.).
Samata M KakkadFrom the Russell H. Morgan Department of Radiology and Radiological Science (K.M.P., B.K., D.J., S.M.K., M.S., A.M., Y.M., M.F.P., M.T.M., S.N., Z.M.B.), Sidney Kimmel Comprehensive Cancer Center (M.F.P., S.N., Z.M.B.), and Department of Radiation Oncology and Molecular Radiation Sciences (Z.M.B.), The Johns Hopkins University School of Medicine, 720 Rutland Ave, Rm 208C Traylor Building, Baltimore, MD 21205; The F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Md (M.T.M.); and Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tuebingen, Tuebingen, Germany (P.K., B.J.P.).ORCID 0000-0002-2959-8320
Meiyappan SolaiyappanFrom the Russell H. Morgan Department of Radiology and Radiological Science (K.M.P., B.K., D.J., S.M.K., M.S., A.M., Y.M., M.F.P., M.T.M., S.N., Z.M.B.), Sidney Kimmel Comprehensive Cancer Center (M.F.P., S.N., Z.M.B.), and Department of Radiation Oncology and Molecular Radiation Sciences (Z.M.B.), The Johns Hopkins University School of Medicine, 720 Rutland Ave, Rm 208C Traylor Building, Baltimore, MD 21205; The F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Md (M.T.M.); and Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tuebingen, Tuebingen, Germany (P.K., B.J.P.).
Akhilesh MishraFrom the Russell H. Morgan Department of Radiology and Radiological Science (K.M.P., B.K., D.J., S.M.K., M.S., A.M., Y.M., M.F.P., M.T.M., S.N., Z.M.B.), Sidney Kimmel Comprehensive Cancer Center (M.F.P., S.N., Z.M.B.), and Department of Radiation Oncology and Molecular Radiation Sciences (Z.M.B.), The Johns Hopkins University School of Medicine, 720 Rutland Ave, Rm 208C Traylor Building, Baltimore, MD 21205; The F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Md (M.T.M.); and Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tuebingen, Tuebingen, Germany (P.K., B.J.P.).
Yelena MironchikFrom the Russell H. Morgan Department of Radiology and Radiological Science (K.M.P., B.K., D.J., S.M.K., M.S., A.M., Y.M., M.F.P., M.T.M., S.N., Z.M.B.), Sidney Kimmel Comprehensive Cancer Center (M.F.P., S.N., Z.M.B.), and Department of Radiation Oncology and Molecular Radiation Sciences (Z.M.B.), The Johns Hopkins University School of Medicine, 720 Rutland Ave, Rm 208C Traylor Building, Baltimore, MD 21205; The F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Md (M.T.M.); and Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tuebingen, Tuebingen, Germany (P.K., B.J.P.).
Marie-France PenetFrom the Russell H. Morgan Department of Radiology and Radiological Science (K.M.P., B.K., D.J., S.M.K., M.S., A.M., Y.M., M.F.P., M.T.M., S.N., Z.M.B.), Sidney Kimmel Comprehensive Cancer Center (M.F.P., S.N., Z.M.B.), and Department of Radiation Oncology and Molecular Radiation Sciences (Z.M.B.), The Johns Hopkins University School of Medicine, 720 Rutland Ave, Rm 208C Traylor Building, Baltimore, MD 21205; The F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Md (M.T.M.); and Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tuebingen, Tuebingen, Germany (P.K., B.J.P.).
Michael T McMahonFrom the Russell H. Morgan Department of Radiology and Radiological Science (K.M.P., B.K., D.J., S.M.K., M.S., A.M., Y.M., M.F.P., M.T.M., S.N., Z.M.B.), Sidney Kimmel Comprehensive Cancer Center (M.F.P., S.N., Z.M.B.), and Department of Radiation Oncology and Molecular Radiation Sciences (Z.M.B.), The Johns Hopkins University School of Medicine, 720 Rutland Ave, Rm 208C Traylor Building, Baltimore, MD 21205; The F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Md (M.T.M.); and Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tuebingen, Tuebingen, Germany (P.K., B.J.P.).
Philipp KnopfFrom the Russell H. Morgan Department of Radiology and Radiological Science (K.M.P., B.K., D.J., S.M.K., M.S., A.M., Y.M., M.F.P., M.T.M., S.N., Z.M.B.), Sidney Kimmel Comprehensive Cancer Center (M.F.P., S.N., Z.M.B.), and Department of Radiation Oncology and Molecular Radiation Sciences (Z.M.B.), The Johns Hopkins University School of Medicine, 720 Rutland Ave, Rm 208C Traylor Building, Baltimore, MD 21205; The F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Md (M.T.M.); and Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tuebingen, Tuebingen, Germany (P.K., B.J.P.).ORCID 0009-0001-3442-9097
Bernd J PichlerFrom the Russell H. Morgan Department of Radiology and Radiological Science (K.M.P., B.K., D.J., S.M.K., M.S., A.M., Y.M., M.F.P., M.T.M., S.N., Z.M.B.), Sidney Kimmel Comprehensive Cancer Center (M.F.P., S.N., Z.M.B.), and Department of Radiation Oncology and Molecular Radiation Sciences (Z.M.B.), The Johns Hopkins University School of Medicine, 720 Rutland Ave, Rm 208C Traylor Building, Baltimore, MD 21205; The F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Md (M.T.M.); and Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tuebingen, Tuebingen, Germany (P.K., B.J.P.).ORCID 0000-0001-6784-5524
Sridhar NimmagaddaFrom the Russell H. Morgan Department of Radiology and Radiological Science (K.M.P., B.K., D.J., S.M.K., M.S., A.M., Y.M., M.F.P., M.T.M., S.N., Z.M.B.), Sidney Kimmel Comprehensive Cancer Center (M.F.P., S.N., Z.M.B.), and Department of Radiation Oncology and Molecular Radiation Sciences (Z.M.B.), The Johns Hopkins University School of Medicine, 720 Rutland Ave, Rm 208C Traylor Building, Baltimore, MD 21205; The F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Md (M.T.M.); and Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tuebingen, Tuebingen, Germany (P.K., B.J.P.).ORCID 0000-0002-6413-7191
Zaver M BhujwallaFrom the Russell H. Morgan Department of Radiology and Radiological Science (K.M.P., B.K., D.J., S.M.K., M.S., A.M., Y.M., M.F.P., M.T.M., S.N., Z.M.B.), Sidney Kimmel Comprehensive Cancer Center (M.F.P., S.N., Z.M.B.), and Department of Radiation Oncology and Molecular Radiation Sciences (Z.M.B.), The Johns Hopkins University School of Medicine, 720 Rutland Ave, Rm 208C Traylor Building, Baltimore, MD 21205; The F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Md (M.T.M.); and Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tuebingen, Tuebingen, Germany (P.K., B.J.P.).ORCID 0000-0002-6617-9360
Johns Hopkins University · USSiemens (Germany) · DEKennedy Krieger Institute · US
Funding
Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI WILLIAM George NELSON · 1985 to 2026
$208.6MTheranostic Imaging of Metastatic Prostate CancerP50CA103175 · NCI · JOHNS HOPKINS UNIVERSITY · PI AMBINDER, RICHARD FREDERICK · 2003 to 2015
$17.9MTraining/Dissemination-Resource for Molecular Imaging Agents in Precision MedicineP41EB024495 · NIBIB · UT SOUTHWESTERN MEDICAL CENTER · PI MARTIN G POMPER · 2017 to 2026
$11.8MSleep and Circadian Dysfunction, Brain and Neurobehavioral Development in AutismP50HD103538 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI S. Ali Fatemi, Bradley L Schlaggar · 2020 to 2026
$9.9MMolecular Imaging and Theranostics of CancerR35CA209960 · NCI · JOHNS HOPKINS UNIVERSITY · PI BHUJWALLA, ZAVER M. · 2017 to 2023
$6.5MHOSTILE ENVIRONMENTS PROMOTE INVASION AND METATASISR01CA082337 · NCI · JOHNS HOPKINS UNIVERSITY · PI BHUJWALLA, ZAVER M. · 1999 to 2024
$5.1MNon-invasive Quantification of Dose-Exposure-Response of PD-L1 Therapeutics at the TumorR01CA236616 · NCI · JOHNS HOPKINS UNIVERSITY · PI NIMMAGADDA, SRIDHAR · 2018 to 2022
$2.3MThe Tumor Microenvironment in Nanoparticle Delivery and FunctionR01CA253617 · NCI · JOHNS HOPKINS UNIVERSITY · PI BHUJWALLA, ZAVER M. · 2020 to 2024
$1.8MNCI NIH HHS P30 CA006973NCI NIH HHS P50 CA103175NCI NIH HHS R01 CA082337NCI NIH HHS R01 CA236616NCI NIH HHS R01 CA253617NCI NIH HHS R35 CA209960NIBIB NIH HHS P41 EB024495NICHD NIH HHS P50 HD103538
Abstract
Purpose To examine the association between hypoxia and programmed cell death ligand 1 (PD-L1) expression using bioluminescence imaging (BLI) and PET/MRI in a syngeneic mouse model of triple-negative breast cancer (TNBC). Materials and Methods PET/MRI and optical imaging were used to determine the role of hypoxia in altering PD-L1 expression using a syngeneic TNBC model engineered to express luciferase under hypoxia. Results Imaging showed a close spatial association between areas of hypoxia and increased PD-L1 expression in the syngeneic murine (4T1) tumor model. Mouse and human TNBC cells exposed to hypoxia exhibited a significant increase in PD-L1 expression, consistent with the in vivo imaging data. The role of hypoxia in increasing PD-L1 expression was further confirmed by using The Cancer Genome Atlas analyses of different human TNBCs. Conclusion These results have identified the potential role of hypoxia in contributing to PD-L1 heterogeneity in tumors by increasing cancer cell PD-L1 expression.
Indexed as
Triple Negative Breast NeoplasmsAnimalsApoptosisB7-H1 AntigenHumansHypoxiaLigandsMagnetic Resonance ImagingMicePositron-Emission TomographyB7-H1 AntigenLigandsBioluminescence ImagingHypoxiaPD-L1PET/MRITriple-Negative Breast Cancer
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