Evidence map›Paper›PMID 37389442›Full record

ArticleJNCI cancer spectrum2023

Risks of alcohol and drug use disorders in prostate cancer survivors: a national cohort study.

Casey Crump, Pär Stattin, James D Brooks, Jan Sundquist, Alexis C Edwards, Weiva Sieh, Kristina Sundquist

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JNCI cancer spectrum, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 2 countries.

Casey CrumpDepartments of Family Medicine and Community Health and of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-2990-1166
Pär StattinDepartment of Surgical Sciences, Uppsala University, Uppsala, Sweden.
James D BrooksDepartment of Urology, Stanford University School of Medicine, Stanford, CA, USA.
Jan SundquistDepartments of Family Medicine and Community Health and of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0001-7228-5015
Alexis C EdwardsDepartment of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
Weiva SiehDepartment of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Kristina SundquistDepartments of Family Medicine and Community Health and of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0001-8031-279X
Lund University · SEIcahn School of Medicine at Mount Sinai · USStanford University · USThe University of Texas MD Anderson Cancer Center · USUppsala University · SEVirginia Commonwealth University · US

Funding

The Etiology of Risk: Alcohol Use Disorder and Suicidal BehaviorR01AA027522 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI Alexis C Edwards, Kristina Sundquist · 2019 to 2026
$3.5M
Long-Term Mental Health Outcomes in Prostate Cancer Survivors and Their PartnersR01CA269553 · NCI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI CRUMP, CASEY, SIEH, WEIVA · 2022 to 2025
$2.1M
NCI NIH HHS R01 CA269553NIAAA NIH HHS R01 AA027522
6 · The paper itself

Abstract

backgroundProstate cancer (PC) survivors may potentially use substances to cope with psychological distress or poorly controlled physical symptoms. Little is known, however, about the long-term risks of alcohol use disorder (AUD) or drug use disorders in men with PC.

methodsA national cohort study was conducted in Sweden of 180 189 men diagnosed with PC between 1998 and 2017 and 1 801 890 age-matched population-based control men. AUD and drug use disorders were ascertained from nationwide records through 2018. Cox regression was used to compute hazard ratios (HRs) while adjusting for sociodemographic factors and prior psychiatric disorders. Subanalyses examined differences by PC treatment from 2005 to 2017.

resultsMen with high-risk PC had increased risks of both AUD (adjusted HR = 1.44, 95% confidence interval [CI] = 1.33 to 1.57) and drug use disorders (adjusted HR = 1.93, 95% CI = 1.67 to 2.24). Their AUD risk was highest in the first year and was no longer significantly elevated 5 years after PC diagnosis, whereas their drug use disorders risk remained elevated 10 years after PC diagnosis (adjusted HR = 2.26, 95% CI = 1.45 to 3.52), particularly opioid use disorder (adjusted HR = 3.07, 95% CI = 1.61 to 5.84). Those treated only with androgen-deprivation therapy had the highest risks of AUD (adjusted HR = 1.91, 95% CI = 1.62 to 2.25) and drug use disorders (adjusted HR = 2.23, 95% CI = 1.70 to 2.92). Low- or intermediate-risk PC was associated with modestly increased risks of AUD (adjusted HR = 1.38, 95% CI = 1.30 to 1.46) and drug use disorders (adjusted HR = 1.19, 95% CI = 1.06 to 1.34).

conclusionsIn this large cohort, men with PC had significantly increased risks of both AUD and drug use disorders, especially those with high-risk PC and treated only with androgen-deprivation therapy. PC survivors need long-term psychosocial support and timely detection and treatment of AUD and drug use disorders.

Indexed as

AlcoholismCancer SurvivorsProstatic NeoplasmsAndrogen AntagonistsAndrogensCohort StudiesEthanolHumansMaleProstateSurvivorsAndrogen AntagonistsAndrogensEthanol

Identifiers

PMID37389442
PMCPMC10393870
OpenAlexW4382631838

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.