Evidence map›Paper›PMID 37389415›Full record

ArticleBioinformatics (Oxford, England)2023

KG-Hub-building and exchanging biological knowledge graphs.

J Harry Caufield, Tim Putman, Kevin Schaper, Deepak R Unni, Harshad Hegde, Tiffany J Callahan, Luca Cappelletti, Sierra A T Moxon, Vida Ravanmehr, Seth Carbon and 16 more

Abstract read
In one paragraph

Article in Bioinformatics (Oxford, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. A change language for ontologies and knowledge graphs.Database : the journal of biological databases and curation · 2025
    Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Using knowledge graphs to infer gene expression in plants.Frontiers in artificial intelligence · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

J Harry CaufieldDivision of Environmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, United States.ORCID 0000-0001-5705-7831
Tim PutmanAnschutz Medical Campus, University of Colorado, Aurora, CO 80045, United States.
Kevin SchaperAnschutz Medical Campus, University of Colorado, Aurora, CO 80045, United States.
Deepak R UnniSIB Swiss Institute of Bioinformatics, Basel 1015, Switzerland.
Harshad HegdeDivision of Environmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, United States.
Tiffany J CallahanDepartment of Biomedical Informatics, Columbia University Irving Medical Center, New York, NY 10032, United States.
Luca CappellettiDepartment of Computer Science, University of Milano, Milan 20126, Italy.
Sierra A T MoxonDivision of Environmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, United States.
Vida RavanmehrDepartment of Lymphoma-Myeloma, MD Anderson Cancer Center, Houston, TX 77030, United States.
Seth CarbonDivision of Environmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, United States.
Lauren E ChanCollege of Public Health and Human Sciences, Oregon State University, Corvallis, OR 97331, United States.
Katherina CortesAnschutz Medical Campus, University of Colorado, Aurora, CO 80045, United States.ORCID 0000-0002-9489-3158
Kent A ShefchekAnschutz Medical Campus, University of Colorado, Aurora, CO 80045, United States.
Glass ElsarboukhAnschutz Medical Campus, University of Colorado, Aurora, CO 80045, United States.
Jim BalhoffRenaissance Computing Institute, University of North Carolina, Chapel Hill, NC 27517, United States.
Tommaso FontanaDipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Milan 20133, Italy.
Nicolas MatentzogluSemanticly, Athens, Greece.
Richard M BruskiewichSTAR Informatics, Delphinai Corporation, Sooke, BC V9Z 0M3, Canada.
Anne E ThessenAnschutz Medical Campus, University of Colorado, Aurora, CO 80045, United States.ORCID 0000-0002-2908-3327
Nomi L HarrisDivision of Environmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, United States.ORCID 0000-0001-6315-3707
Monica C Munoz-TorresAnschutz Medical Campus, University of Colorado, Aurora, CO 80045, United States.
Melissa A HaendelAnschutz Medical Campus, University of Colorado, Aurora, CO 80045, United States.ORCID 0000-0001-9114-8737
Peter N RobinsonThe Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, United States.ORCID 0000-0002-0736-9199
Marcin P JoachimiakDivision of Environmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, United States.
Christopher J MungallDivision of Environmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, United States.ORCID 0000-0002-6601-2165
Justin T ReeseDivision of Environmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, United States.ORCID 0000-0002-2170-2250

Funding

The Monarch Initiative: Linking Diseases to Model Organism ResourcesR24OD011883 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HAENDEL, MELISSA A, MUNGALL, CHRISTOPHER J · 2012 to 2024
$16.0M
Computational Bioscience Program Training GrantT15LM009451 · NLM · UNIVERSITY OF COLORADO DENVER · PI Katherina Kechris-Mays, Arjun Krishnan · 2007 to 2026
$11.7M
Improvements to the LinkML framework to support the Phenomics First open science resourceRM1HG010860 · NHGRI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HAENDEL, MELISSA A, MUNGALL, CHRISTOPHER J · 2020 to 2024
$10.3M
The Human Phenotype Ontology: Accelerating Computational Integration of Clinical Data for GenomicsU24HG011449 · NHGRI · JACKSON LABORATORY · PI Peter Nicholas Robinson · 2021 to 2026
$6.7M
A Common Dialect for Infrastructure and Services in TranslatorOT2TR003449 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BIZON, CHRISTOPHER, BRUSH, MATTHEW H. · 2020 to 2024
$5.6M
BioPortal: An Expansive Knowledgebase of Biomedical Entities and RelationsU24GM143402 · NIGMS · STANFORD UNIVERSITY · PI MUSEN, MARK A · 2021 to 2024
$4.5M
Illuminating the Druggable Genome by Knowledge GraphsU01CA239108 · NCI · JACKSON LABORATORY · PI MUNGALL, CHRISTOPHER J, OPREA, TUDOR I · 2019 to 2021
$1.7M
NCATS NIH HHS OT2 TR003449NCI NIH HHS U01 CA239108NHGRI NIH HHS #1RM1HG010860-01NHGRI NIH HHS RM1 HG010860NHGRI NIH HHS U24 HG011449NIGMS NIH HHS U24 GM143402NLM NIH HHS T15 LM009451
6 · The paper itself

Abstract

motivationKnowledge graphs (KGs) are a powerful approach for integrating heterogeneous data and making inferences in biology and many other domains, but a coherent solution for constructing, exchanging, and facilitating the downstream use of KGs is lacking.

resultsHere we present KG-Hub, a platform that enables standardized construction, exchange, and reuse of KGs. Features include a simple, modular extract-transform-load pattern for producing graphs compliant with Biolink Model (a high-level data model for standardizing biological data), easy integration of any OBO (Open Biological and Biomedical Ontologies) ontology, cached downloads of upstream data sources, versioned and automatically updated builds with stable URLs, web-browsable storage of KG artifacts on cloud infrastructure, and easy reuse of transformed subgraphs across projects. Current KG-Hub projects span use cases including COVID-19 research, drug repurposing, microbial-environmental interactions, and rare disease research. KG-Hub is equipped with tooling to easily analyze and manipulate KGs. KG-Hub is also tightly integrated with graph machine learning (ML) tools which allow automated graph ML, including node embeddings and training of models for link prediction and node classification. AVAILABILITY AND IMPLEMENTATION: https://kghub.org.

Indexed as

Biological OntologiesCOVID-19HumansMachine LearningPattern Recognition, AutomatedRare Diseases

Identifiers

PMID37389415
PMCPMC10336030

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.