Evidence map›Paper›PMID 37389311›Full record

ReviewSafety and health at work2023

Firefighting and Cancer: A Meta-analysis of Cohort Studies in the Context of Cancer Hazard Identification.

Nathan L DeBono, Robert D Daniels, Laura E Beane Freeman, Judith M Graber, Johnni Hansen, Lauren R Teras, Tim Driscoll, Kristina Kjaerheim, Paul A Demers, Deborah C Glass and 6 more

Registry-linked trialAbstract readReview
In one paragraph

Review in Safety and health at work, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06931561 (Occupational Cancer Screening in Firefighters), which is not on this map. Cited by 29 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06931561 narecruitingnot on this mapstarted 2025, after this paper: background citation

Occupational Cancer Screening in Firefighters: A Pilot Study Within the Inova Health System

TypeinterventionalSponsorInova Health Care ServicesRan2025 to 2028Enrolled800ConditionsCancerArmsWhole Body MRI, Whole Body Ultrasound, MCD Assay, Occupational Exposure Questionnaire
3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Bladder cancer risk factors: a comprehensive umbrella review of meta-analyses.International journal of surgery (London, England) · 2026
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Nathan L DeBonoEvidence Synthesis and Classification Branch, International Agency for Research on Cancer, Lyon, France.
Robert D DanielsNational Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, USA.
Laura E Beane FreemanOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, USA.
Judith M GraberDepartment of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, USA.
Johnni HansenDanish Cancer Society Research Centre, Copenhagen, Denmark.
Lauren R TerasAmerican Cancer Society, Atlanta, USA.
Tim DriscollSydney School of Public Health, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.
Kristina KjaerheimDepartment of Research, Cancer Registry of Norway, Oslo, Norway.
Paul A DemersOccupational Cancer Research Centre, Ontario Health, Toronto, Canada.
Deborah C GlassSchool of Epidemiology and Preventative Medicine, Monash University, Melbourne, Australia.
David KriebelLowell Center for Sustainable Production, University of Massachusetts Lowell, Lowell, USA.
Tracy L KirkhamOccupational Cancer Research Centre, Ontario Health, Toronto, Canada.
Roland WedekindEvidence Synthesis and Classification Branch, International Agency for Research on Cancer, Lyon, France.
Adalberto M FilhoEvidence Synthesis and Classification Branch, International Agency for Research on Cancer, Lyon, France.
Leslie StaynerEvidence Synthesis and Classification Branch, International Agency for Research on Cancer, Lyon, France.
Mary K Schubauer-BeriganEvidence Synthesis and Classification Branch, International Agency for Research on Cancer, Lyon, France.

Funding

EVALUATION OF CARCINOGENIC RISKS TO HUMANSU01CA033193 · NCI · INTERNATIONAL AGENCY FOR RES ON CANCER · PI SCHUBAUER-BERIGAN, MARY K. · 1985 to 2020
$16.5M
IARC Monographs on the Identification of Carcinogenic Hazards to HumansR01CA033193 · NCI · INTERNATIONAL AGENCY FOR RES ON CANCER · PI SCHUBAUER-BERIGAN, MARY K. · 2021 to 2025
$4.9M
NCI NIH HHS R01 CA033193NCI NIH HHS U01 CA033193World Health Organization 001
6 · The paper itself

Abstract

Objective: We performed a meta-analysis of epidemiological results for the association between occupational exposure as a firefighter and cancer as part of the broader evidence synthesis work of the Methods: A systematic literature search was conducted to identify cohort studies of firefighters followed for cancer incidence and mortality. Studies were evaluated for the influence of key biases on results. Random-effects meta-analysis models were used to estimate the association between ever-employment and duration of employment as a firefighter and risk of 12 selected cancers. The impact of bias was explored in sensitivity analyses. Results: Among the 16 included cancer incidence studies, the estimated meta-rate ratio, 95% confidence interval (CI), and heterogeneity statistic (I Conclusions: There is epidemiological evidence to support a causal relationship between occupational exposure as a firefighter and certain cancers. Challenges persist in the body of evidence related to the quality of exposure assessment, confounding, and medical surveillance bias.

Indexed as

CancerFirefighterHazard

Identifiers

PMID37389311
PMCPMC10300491

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.