Evidence map›Paper›PMID 37389215›Full record

ArticleFrontiers in cellular and infection microbiology2023

Atopic dermatitis-derived

Antonietta Lucia Conte, Francesca Brunetti, Massimiliano Marazzato, Catia Longhi, Linda Maurizi, Giammarco Raponi, Anna Teresa Palamara, Sara Grassi, Maria Pia Conte

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In one paragraph

Article in Frontiers in cellular and infection microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Biofilm · 2024
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  12. Genomic and functional divergence ofMicrobiology spectrum · 2024
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  13. Review
  14. Towards sustainable antimicrobial therapies forSustainable microbiology · 2024
    Review
  15. Understanding the role ofFrontiers in medicine · 2024
    Review
  16. Antibiotics (Basel, Switzerland) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Antonietta Lucia ConteDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Francesca BrunettiDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Massimiliano MarazzatoDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Catia LonghiDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Linda MauriziDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Giammarco RaponiDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Anna Teresa PalamaraDepartment of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
Sara GrassiDermatology Clinic, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
Maria Pia ConteDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Atopic dermatitis (AD) is a chronic inflammatory skin condition whose pathogenesis involves genetic predisposition, epidermal barrier dysfunction, alterations in the immune responses and microbial dysbiosis. Clinical studies have shown a link between Methods: WGS analyses were performed on 38 Results: Strains isolated from AD patients revealed a high degree of genetic heterogeneity and a shared set of virulence factors and antimicrobial resistance genes, suggesting that no genotype and genomic content are uniquely associated with AD. The same strains were characterized by a lower variability in terms of gene content, indicating that the inflammatory conditions could exert a selective pressure leading to the optimization of the gene repertoire. Furthermore, genes related to specific mechanisms, like post-translational modification, protein turnover and chaperones as well as intracellular trafficking, secretion and vesicular transport, were significantly more enriched in AD strains. Phenotypic analysis revealed that all of our AD strains were strong or moderate biofilm producers, while less than half showed invasive capabilities. Conclusions: We conclude that in AD skin, the functional role played by

Indexed as

Dermatitis, AtopicGenotypeHumansMultilocus Sequence TypingSkinStaphylococcus aureusantibiotic resistanceatopic dermatitisbiofilmin silico genotypepan-genomeStaphylococcus aureuswhole-genome sequencing

Identifiers

PMID37389215
PMCPMC10303148

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.