Evidence map›Paper›PMID 37389123›Full record

ArticleFrontiers in physiology2023

Inappropriate activation of the renin-angiotensin system improves cardiac tolerance to ischemia/reperfusion injury in rats with late angiotensin II-dependent hypertension.

Zuzana Husková, Soňa Kikerlová, Matúš Miklovič, Petr Kala, František Papoušek, Jan Neckář

Abstract read
In one paragraph

Article in Frontiers in physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zuzana HuskováCenter of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czechia.
Soňa KikerlováCenter of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czechia.
Matúš MiklovičCenter of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czechia.
Petr KalaCenter of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czechia.
František PapoušekLaboratory of Developmental Cardiology, Institute of Physiology, Academy of Sciences of the Czech Republic (ASCR), Prague, Czechia.
Jan NeckářCenter of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czechia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of the study was to clarify the role of the interplay between hypertension and the renin-angiotensin system (RAS) in the pathophysiology of myocardial ischemia/reperfusion (I/R) injury. We hypothesized that in the late phase of hypertension with already developed signs of end-organ damage, inappropriate RAS activation could impair cardiac tolerance to I/R injury. Experiments were performed in male

Indexed as

ANG II-dependent hypertensionAT1 receptor antagonistischemia/reperfusion injuryP-V analysisrenin-angiotensin system

Identifiers

PMID37389123
PMCPMC10301744

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.