Evidence map›Paper›PMID 37389109›Full record

ReviewWorld journal of gastrointestinal oncology2023

Role of neoadjuvant therapy for nonmetastatic pancreatic cancer: Current evidence and future perspectives.

Gianluca Cassese, Ho-Seong Han, Yoo-Seok Yoon, Jun Suh Lee, Boram Lee, Antonio Cubisino, Fabrizio Panaro, Roberto Ivan Troisi

Abstract readReview
In one paragraph

Review in World journal of gastrointestinal oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Radiochemotherapy in Pancreatic Cancer.Current oncology (Toronto, Ont.) · 2024
    Review
  6. Article
  7. Unbiased Quantitative Proteomics of Organoid Models of Pancreatic Cancer.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Gianluca CasseseDepartment of Clinical Medicine and Surgery, Division of Minimally Invasive HPB Surgery and Transplantation Service, Federico II University Hospital, Naples 80131, Italy.
Ho-Seong HanDepartment of Surgery, Seoul National University College of Medicine, Seongnam 13620, Gyeonggi-do, South Korea. hanhs@snubh.org.
Yoo-Seok YoonDepartment of Surgery, Seoul National University College of Medicine, Seongnam 13620, Gyeonggi-do, South Korea.
Jun Suh LeeDepartment of Surgery, Seoul National University College of Medicine, Seongnam 13620, Gyeonggi-do, South Korea.
Boram LeeDepartment of Surgery, Seoul National University College of Medicine, Seongnam 13620, Gyeonggi-do, South Korea.
Antonio CubisinoDepartment of HPB Surgery and Transplantation, Beaujon Hospital, Clichy 92110, France.
Fabrizio PanaroDepartment of Digestive Surgery and Liver Transplantation, CHU Montpellier, Montpellier 34100, France.
Roberto Ivan TroisiDepartment of Clinical Medicine and Surgery, Division of Minimally Invasive HPB Surgery and Transplantation Service, Federico II University Hospital, Naples 80131, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pancreatic adenocarcinoma (PDAC) is one of the most common and lethal human cancers worldwide. Surgery followed by adjuvant chemotherapy offers the best chance of a long-term survival for patients with PDAC, although only approximately 20% of the patients have resectable tumors when diagnosed. Neoadjuvant chemotherapy (NACT) is recommended for borderline resectable pancreatic cancer. Several studies have investigated the role of NACT in treating resectable tumors based on the recent advances in PDAC biology, as NACT provides the potential benefit of selecting patients with favorable tumor biology and controls potential micro-metastases in high-risk patients with resectable PDAC. In such challenging cases, new potential tools, such as ct-DNA and molecular targeted therapy, are emerging as novel therapeutic options that may improve old paradigms. This review aims to summarize the current evidence regarding the role of NACT in treating non-metastatic pancreatic cancer while focusing on future perspectives in light of recent evidence.

Indexed as

Borderline resectableLocally advanced pancreatic cancerNeoadjuvant chemotherapyPancreatic cancerPancreatic duct adenocarcinoma

Identifiers

PMID37389109
PMCPMC10302990

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.