Evidence map›Paper›PMID 37389100›Full record

ReviewAsia Pacific allergy2023

Real-world data: A relevant component in the framework of scientific evidence.

Giorgio W Canonica, Lorenzo Del Moro, Giovanni Costanzo, Emanuele Nappi, Giovanni Paoletti

Abstract readReview
In one paragraph

Review in Asia Pacific allergy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Giorgio W CanonicaDepartment of Biomedical Sciences, Humanitas University, Milan, Italy.
Lorenzo Del MoroAsthma and Allergy Unit-IRCCS Humanitas Research Hospital, Milan, Italy.ORCID https://orcid.org/0000-0002-4002-933X
Giovanni CostanzoAsthma and Allergy Unit-IRCCS Humanitas Research Hospital, Milan, Italy.
Emanuele NappiAsthma and Allergy Unit-IRCCS Humanitas Research Hospital, Milan, Italy.
Giovanni PaolettiAsthma and Allergy Unit-IRCCS Humanitas Research Hospital, Milan, Italy.ORCID https://orcid.org/0000-0003-3953-9225

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Explanatory randomized controlled clinical trials test hypotheses to see if the intervention causes an outcome of interest in optimal circumstances, that is, established by selecting patients based on inclusion and exclusion criteria and controlled environments. They assess the "efficacy" of an intervention. On the contrary, it is crucial for society to address issues related to real-world clinical practices. This need can be fulfilled by real-world studies. We discuss the challenges in obtaining real-world evidence in asthma, debating the importance of including patients who are typically excluded from randomized controlled clinical trials to ensure the generalizability of the results. We conclude by discussing the integration of real-world evidence in guidelines and the need for standard rules to use real-world evidence in guidelines.

Indexed as

Asthmaeffectivenessguidelinesreal-world evidence

Identifiers

PMID37389100
PMCPMC10166240

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.