Evidence map›Paper›PMID 37389065›Full record

ArticleHeliyon2023

Plexin D1 mediates disturbed flow-induced M1 macrophage polarization in atherosclerosis.

Suhui Zhang, Yingqian Zhang, Peng Zhang, Zechen Wei, Mingrui Ma, Wei Wang, Wei Tong, Feng Tian, Hui Hui, Jie Tian and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Suhui ZhangMedical School of Chinese PLA, Chinese PLA General Hospital, Beijing, 100853, China.
Yingqian ZhangSenior Department of Cardiology, The Sixth Medical Center of PLA General Hospital, Beijing, 100048, China.
Peng ZhangSchool of Computer and Information Technology, Beijing Jiaotong University, Beijing, 100044, China.
Zechen WeiCAS Key Laboratory of Molecular Imaging, Beijing Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China.
Mingrui MaMedical School of Chinese PLA, Chinese PLA General Hospital, Beijing, 100853, China.
Wei WangSenior Department of Cardiology, The Sixth Medical Center of PLA General Hospital, Beijing, 100048, China.
Wei TongSenior Department of Cardiology, The Sixth Medical Center of PLA General Hospital, Beijing, 100048, China.
Feng TianSenior Department of Cardiology, The Sixth Medical Center of PLA General Hospital, Beijing, 100048, China.
Hui HuiCAS Key Laboratory of Molecular Imaging, Beijing Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China.
Jie TianCAS Key Laboratory of Molecular Imaging, Beijing Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China.
Yundai ChenSenior Department of Cardiology, The Sixth Medical Center of PLA General Hospital, Beijing, 100048, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atherosclerosis preferentially develops at bifurcations exposed to disturbed flow. Plexin D1 (PLXND1) responds to mechanical forces and drives macrophage accumulation in atherosclerosis. Here, multiple strategies were used to identify the role of PLXND1 in site-specific atherosclerosis. Using computational fluid dynamics and three-dimensional light-sheet fluorescence-microscopy, the elevated PLXND1 in M1 macrophages was mainly distributed in disturbed flow area of ApoE

Indexed as

AtherosclerosisBifurcation lesionsDisturbed flowMacrophage polarizationPlexin D1

Identifiers

PMID37389065
PMCPMC10300222

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.