Evidence map›Paper›PMID 37389053›Full record

ArticleHeliyon2023

Restorative effects of gallic acid against sub-chronic hepatic toxicity of co-exposure to zinc oxide nanoparticles and arsenic trioxide in male rats.

Khaled Abo-El-Sooud, Yasmina M Abd-El Hakim, Mohamed M M Hashem, Abeer E El-Metwally, Bayan A Hassan, Hayat H M El-Nour

Abstract read
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In one paragraph

Article in Heliyon, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Khaled Abo-El-SooudDepartment of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza 12613, Egypt.
Yasmina M Abd-El HakimDepartment of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44519, Egypt.
Mohamed M M HashemDepartment of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza 12613, Egypt.
Abeer E El-MetwallyPathology Department, Animal Reproduction Research Institute, Giza 3514805, Egypt.
Bayan A HassanPharmacology Department, Faculty of Pharmacy, Future University, Cairo 11835, Egypt.
Hayat H M El-NourBiology of Reproduction Department, Animal Reproduction Research Institute, Giza 3514805, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and objectives: This study aimed to assess the effect of zinc oxide nanoparticles (ZNPs) and/or arsenic trioxide (ATO) exposure on the liver of adult male Sprague Dawley rats. Moreover, the probable ameliorative impact of gallic acid (GA) against ZNPs and ATO-induced hepatotoxicity and the possible underlying mechanisms were evaluated. Methods: Sixty male Sprague Dawley rats were distributed into six groups. The 1 Results: ZNPs, ATO, and ZNPs+ATO-exposed rats showed significantly ( Conclusion: Overall, GA oral dosing significantly mitigated the negative effects of ZNPs and ATO on the liver by improving the antioxidant defense system and controlling apoptotic changes.

Indexed as

Arsenic trioxideBaxBcl-2BilirubinGallic acidGPxMDAZinc oxide nanoparticles

Identifiers

PMID37389053
PMCPMC10300221

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.