Evidence map›Paper›PMID 37389026›Full record

ArticleContinence (Amsterdam, Netherlands)2023

Soluble Guanylate Cyclase Activators to Treat Benign Prostatic Hyperplasia and associated LUTS.

A J Kanai, K-E Andersson, L A Birder, C H Fry

Abstract read
In one paragraph

Article in Continence (Amsterdam, Netherlands), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. What do we really know about the external urethral sphincter?Continence (Amsterdam, Netherlands) · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

A J KanaiUniversity of Pittsburgh, Department of Medicine, Renal-Electrolyte Division, USA.
K-E AnderssonLund University, Division of Clinical Chemistry and Pharmacology, Lund, Sweden.
L A BirderUniversity of Pittsburgh, Department of Medicine, Renal-Electrolyte Division, USA.
C H FryUniversity of Bristol, School of Physiology, Pharmacology, and Neuroscience, UK.

Funding

Urothelium in Detrusor OveractivityP01DK093424 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DEGROAT, WILLIAM C · 2013 to 2017
$7.9M
PDE5 Inhibition of Afferents and Interstitial Cells in Overactive Mouse BladdersR01DK098361 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BIRDER, LORI A, KANAI, ANTHONY JOHN · 2014 to 2024
$5.7M
Contribution of Stress Induced Autonomic and Urothelial Dysregulation to IC/BPSR01DK115476 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BIRDER, LORI A, RODRIGUEZ, LARISSA · 2018 to 2022
$3.5M
Bladder Mucosal Dysfunction During AgingR01AG056944 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI APODACA, GERARD L, BIRDER, LORI A · 2018 to 2022
$3.2M
Novel Mechanistic Approaches in Prevention, Treatment and Non-Invasive Assessment of Radiation Cystitis in MiceR01CA251341 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KANAI, ANTHONY JOHN · 2021 to 2024
$1.8M
NCI NIH HHS R01 CA251341NIA NIH HHS R01 AG056944NIDDK NIH HHS P01 DK093424NIDDK NIH HHS R01 DK098361NIDDK NIH HHS R01 DK115476
6 · The paper itself

Abstract

This review summarises the presentations during a workshop session entitled "The Use of Soluble Guanylate Cyclase Activators to Treat Benign Prostatic Hyperplasia, Obstruction and Fibrosis - Mechanistic Concepts and Clinical Implications" at the International Continence Society (ICS) 2021 Melbourne Virtual meeting. Benign prostatic hyperplasia (BPH) is a highly prevalent condition that can result in bladder outflow obstruction (BOO) and development of lower urinary tract symptoms (LUTS), and by 80 years of age is present in about 75% of men. Current pharmacological therapies include

Indexed as

8-aminoguanine (8AG)Benign prostatic hyperplasia (BPH)Bladder outlet obstruction (BOO)Lower urinary tract symptoms (LUTS)Purine nucleotide phosphorylase (PNPase)Soluble guanylate cyclase (sGC) activators

Identifiers

PMID37389026
PMCPMC10310070

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.