Evidence map›Paper›PMID 37387778›Full record

ArticleInternational journal of pharmaceutics: X2023

End-point determination of heterogeneous formulations using inline torque measurements for a high-shear wet granulation process.

Ashley Dan, Haresh Vaswani, Alice Šimonová, Aleksandra Grząbka-Zasadzińska, Jingzhe Li, Koyel Sen, Shubhajit Paul, Yin-Chao Tseng, Rohit Ramachandran

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of pharmaceutics: X, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ashley DanDepartment of Chemical and Biochemical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ, USA 08854.
Haresh VaswaniDepartment of Chemical and Biochemical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ, USA 08854.
Alice ŠimonováDepartment of Analytical Chemistry, Charles University, Hlavova 2030/8, 12843, Prague, Czech Republic.
Aleksandra Grząbka-ZasadzińskaInstitute of Chemical Technology and Engineering, Poznan University of Technology, ul. Berdychowo 4, 60-965 Poznań, Poland.
Jingzhe LiBoehringer Ingelheim Pharmaceuticals Inc, 900 Ridgebury Rd, Ridgefield, CT 06877, United States of America.
Koyel SenBoehringer Ingelheim Pharmaceuticals Inc, 900 Ridgebury Rd, Ridgefield, CT 06877, United States of America.
Shubhajit PaulBoehringer Ingelheim Pharmaceuticals Inc, 900 Ridgebury Rd, Ridgefield, CT 06877, United States of America.
Yin-Chao TsengBoehringer Ingelheim Pharmaceuticals Inc, 900 Ridgebury Rd, Ridgefield, CT 06877, United States of America.
Rohit RamachandranDepartment of Chemical and Biochemical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ, USA 08854.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, the torque profiles of heterogeneous granulation formulations with varying powder properties in terms of particle size, solubility, deformability, and wettability, were studied, and the feasibility of identifying the end-point of the granulation process for each formulation based on the torque profiles was evaluated. Dynamic median particle size (d

Indexed as

End-point determinationGrowth regimesOver-granulationPorosityTorqueWet granulation

Identifiers

PMID37387778
PMCPMC10300204

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.