ArticlePlant biotechnology journal2023
MdNAC104 positively regulates apple cold tolerance via CBF-dependent and CBF-independent pathways.
Article in Plant biotechnology journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed.
- Multifaceted mechanisms underlying species- and cultivar-associated differential anthocyanin accumulation in fruits.Horticulture research · 2026Article
- Enhancing cold tolerance through HubZIP6-mediated CBF activation and salicylic acid signaling in pitaya.Molecular horticulture · 2026Article
- Genome‑Wide Identification of NAC Transcription Factors in Elymus sibiricus and Functional Characterisation of EsNAC29 in Light Inhibition.Plant, cell & environment · 2026Article
- NtWHY1 negatively regulates tobacco cold tolerance via interfering with flavonoid biosynthesis.Plant cell reports · 2026Article
- Integrated Transcriptomic and Metabolomic Analysis Reveals Molecular Responses Associated with Foliar Selenium Treatment Under Cold Stress in Rapeseed (International journal of molecular sciences · 2026Article
- Engineering climate-resilient horticultural crops: advances in transcriptional regulation, genome editing, and synthetic networks.Horticulture research · 2026Article
- Regulatory insights underlying apple to cold stress.Horticulture research · 2026Article
- Functional Characterization and Potential Regulatory Role ofInternational journal of molecular sciences · 2026Article
- AaSIZ1-Mediated SUMOylation of AaMYB31 Positively Regulates Freezing Tolerance in Actinidia arguta.Plant biotechnology journal · 2026Article
- Cold storage delays peach fruit softening via mMolecular horticulture · 2026Article
- The MdICE1/MdFAMA-MdTYDC Transcriptional Module Confers Cold Tolerance by Regulating Dopamine Metabolism in Apple.Plant biotechnology journal · 2026Article
- Lipid remodeling and phosphatidic acid signaling maintain the vigor of recalcitrant Panax notoginseng seeds under low temperature.BMC plant biology · 2026Article
- PaMYBS3 balances cold tolerance and growth inhibition as a cold acclimation strategy in Plumbago auriculata L.BMC plant biology · 2026Article
- The Transcription Factors NFYA1 and GBF3 Jointly Regulate CHS2 to Promote Tangeretin Accumulation and Cold Tolerance in Citrus.Plant biotechnology journal · 2026Article
- Cold-tolerant bacteria from alpine Rosaceae plants modulate transcriptional responses of apple and strawberry plantlets to freezing stress.Frontiers in plant science · 2026Article
- Chromatin accessibility dynamics and a hierarchical transcriptional regulatory network for shoot apex cold stress inForestry research · 2026Article
- A Repression-Activation System Involving miR164a-NACs Regulates Tissue-Specific Anthocyanin Accumulation in Peach Fruit.Plant biotechnology journal · 2025Article
- The MdHB7L-MdICE1L-MdHOS1 Module Fine-Tunes Apple Cold Response via CBF-Dependent and CBF-Independent Pathways.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Strigolactones enhance apple drought resistance via the MsABI5-MsSMXL1-MsNAC022 cascade.Horticulture research · 2025Article
- Genome-wide identification and expression profiles of NAC transcription factors in Poncirus trifoliata reveal their potential roles in cold tolerance.BMC plant biology · 2025Article
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Authors and funding
12 authors.
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Abstract
Low temperature is the main environmental factor affecting the yield, quality and geographical distribution of crops, which significantly restricts development of the fruit industry. The NAC (NAM, ATAF1/2 and CUC2) transcription factor (TF) family is involved in regulating plant cold tolerance, but the mechanisms underlying these regulatory processes remain unclear. Here, the NAC TF MdNAC104 played a positive role in modulating apple cold tolerance. Under cold stress, MdNAC104-overexpressing transgenic plants exhibited less ion leakage and lower ROS (reactive oxygen species) accumulation, but higher contents of osmoregulatory substances and activities of antioxidant enzymes. Transcriptional regulation analysis showed that MdNAC104 directly bound to the MdCBF1 and MdCBF3 promoters to promote expression. In addition, based on combined transcriptomic and metabolomic analyses, as well as promoter binding and transcriptional regulation analyses, we found that MdNAC104 stimulated the accumulation of anthocyanin under cold conditions by upregulating the expression of anthocyanin synthesis-related genes, including MdCHS-b, MdCHI-a, MdF3H-a and MdANS-b, and increased the activities of the antioxidant enzymes by promoting the expression of the antioxidant enzyme-encoding genes MdFSD2 and MdPRXR1.1. In conclusion, this study revealed the MdNAC104 regulatory mechanism of cold tolerance in apple via CBF-dependent and CBF-independent pathways.
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